DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and HisCl1

DIOPT Version :10

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_731632.1 Gene:HisCl1 / 41426 FlyBaseID:FBgn0037950 Length:426 Species:Drosophila melanogaster


Alignment Length:344 Identity:82/344 - (23%)
Similarity:142/344 - (41%) Gaps:62/344 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 HFATGGLANPD----AKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTN 74
            |:.: .|:.||    ..:.||.     ||..:.:|..:   .|...:.:..|..:|.::....|:
  Fly    49 HYES-SLSLPDILPIPSKTYDK-----NRAPKLLGQPT---VVYFHVTVLSLDSINEESMTYVTD 104

  Fly    75 VWVEQEWNDYKLKWNPDDYG------GVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAI--- 130
            :::.|.|.|.:|:. |::..      .||.||    .||.|| ..:.||.   :||....:|   
  Fly   105 IFLAQSWRDPRLRL-PENMSEQYRILDVDWLH----SIWRPD-CFFKNAK---KVTFHEMSIPNH 160

  Fly   131 ---LHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE 192
               |:|...:::.........|.:..|.:|.|.|.|.|...|.::.  :.||..:....|...:.
  Fly   161 YLWLYHDKTLLYMSKLTLVLSCAMKFESYPHDTQICSMMIESLSHT--VEDLVFIWNMTDPLVVN 223

  Fly   193 VGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPY-------LDIVFNLTLRRKTLFYTVNLIIP 250
            ..|:|....||             ..:.:.|...|       |.||||  |||:..::..:..||
  Fly   224 TEIELPQLDIS-------------NNYTTDCTIEYSTGNFTCLAIVFN--LRRRLGYHLFHTYIP 273

  Fly   251 CVGISFLSVLVFYL-PSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLV 314
            ...|..:|.:.|:: |.....:::|.::.||:|........:.:||.|. |..:..::....:.|
  Fly   274 SALIVVMSWISFWIKPEAIPARVTLGVTSLLTLATQNTQSQQSLPPVSY-VKAIDVWMSSCSVFV 337

  Fly   315 TLSVVVTIAVLNVNFRSPV 333
            .|| ::..||:| ||..||
  Fly   338 FLS-LMEFAVVN-NFMGPV 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 LGIC_ECD_nAChR_proto_alpha-like 24..242 CDD:349832 55/240 (23%)
LIC 27..530 CDD:455710 78/327 (24%)
Cys-loop 149..163 CDD:349832 5/13 (38%)
HisCl1NP_731632.1 LGIC_ECD_HisCl 78..262 CDD:349793 48/212 (23%)
Cys-loop 182..196 CDD:349793 5/13 (38%)
LGIC_TM_anion 265..>351 CDD:349851 21/88 (24%)
TM1 helix 265..288 CDD:349851 5/22 (23%)
TM2 helix 292..316 CDD:349851 4/23 (17%)
TM3 helix 324..350 CDD:349851 6/27 (22%)

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