Protein Alignment nAChRalpha1 and Grd

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_524131.1
• Gene: Grd / 39984
• FlyBaseID: FBgn0001134
• Length: 686
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 116/598 - (19%)
• Similarity: 214/598 - (35%)
• Gaps: 154/598 - (25%)

  Fly    28 LYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDD 92
            |.|:||..|:..||| .......|:::.:.:..:..::..:...:.:.:..|.|.|.:|.:.
  Fly   112 LLDNLLRGYDNSIRP-DFGGPPATIEVDIMVRSMGPISEVDMTYSMDCYFRQSWVDKRLAFE--- 172

  Fly    93 YGGVDTLHVPSE---HIWLPDIVLYNNADGNYEVTIMT--KAI-LHHTGKVVWKPPAIYKSFCEI 151
             |..|||.:...   .||.||...||... :|..||.|  |.: ::..|:|::......|:.|.:
  Fly   173 -GAQDTLALSVSMLARIWKPDTYFYNGKQ-SYLHTITTPNKFVRIYQNGRVLYSSRLTIKAGCPM 235

  Fly   152 DVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQ---TADSDNIEVG-IDLQDYYISVEWDIM--- 209
            ::..||.|.|.|.:||||:.|....|..|..|:   .|.::::::. .||.|.......||:
  Fly   236 NLADFPMDIQKCPLKFGSFGYTTSDVIYRWNKERPPVAIAEDMKLSQFDLVDCPAGNLTDIVYKA 300

  Fly   210 --------------------RV------PAVRNEKFYSC-------------------------- 222
                                :|      ||.:|:.....
  Fly   301 AAPRPQRRPFNNKDPPRPTSKVMTTFAGPAAKNQHVRGTGLKLDKGAFGTGRDATGGSGSTTGLS 365

  Fly   223 ------CEEP--YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSD-SGEKISLCISI 278
                  ...|  |..::.|..|:|....:.:.:..||..:..||.:.|:|..: :.:::||.|:.
  Fly   366 GTITLETNHPSEYSMLMVNFHLQRHMGNFLIQVYGPCCLLVVLSWVSFWLNREATADRVSLGITT 430

  Fly   279 LLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFR------------- 330
            :|::|...|.....:|..|....|  .:.:|.......:.::..||::...:
  Fly   431 VLTMTFLGLEARTDLPKVSYPTAL--DFFVFLSFGFIFATILQFAVVHYYTKYGSGECYFIIEEL 493

  Fly   331 ---------SPVTHRMAPWVQRLFIQILPKLLC-IERPKKEEPEEDQPPEVLTDVYHLPPDVDKF 385
                     .|:|.......:....:::|..:| |..|         ||         |..:...
  Fly   494 DSESGESETEPLTSDFRGSTESKIYEVIPLSMCAISMP---------PP---------PTRLGML 540

  Fly   386 VNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS 450
            .:.:.:..:..:|:.::.....||....        .:||...|     .:|:....:.|..:.:
  Fly   541 TSRNRRPRNRRHGLWSMKLLGLFDWRRR--------RKPPRADS-----DEDEDDEQTQLRANEA 592

  Fly   451 PGCCPAAAAAAAADLSPTFEKP---------YAR-EMEKTIEGSRFIAQHVKNKDKFESVEEDWK 505
            |....|||||.||..:.....|         |.| |||...:|        |...::.||.:..:
  Fly   593 PTTSAAAAAAQAAAQAARISPPTGGRRRMSYYRREEMEARRKG--------KRTPQYNSVSKIDR 649

  Fly   506 YVAMVLDRMFLWI 518
            ...:|...:|:.|
  Fly   650 ASRIVFPLLFILI 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	60/286 (21%)
		LIC	27..530	CDD:455710	116/598 (19%)
		Cys-loop	149..163	CDD:349832	5/13 (38%)
Grd	NP_524131.1	LIC	111..670	CDD:455710	116/598 (19%)
		LGIC_ECD_GABAR_GRD-like	132..300	CDD:349808	43/172 (25%)
		Cys-loop	233..247	CDD:349808	5/13 (38%)