Protein Alignment nAChRalpha1 and deg-3

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001379138.1
• Gene: deg-3 / 3565200
• WormBaseID: WBGene00000951
• Length: 564
• Species: Caenorhabditis elegans
• Alignment Length: 585
• Identity: 150/585 - (25%)
• Similarity: 261/585 - (44%)
• Gaps: 122/585 - (20%)

  Fly    20 LANPDAKRLYDDLLS--NYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWN 82
            :.|....||...|||  .|:..:||:.::...|.|.:.:.|.|:|:|:..:|.:..|||:.|:|.
 Worm    46 MKNVPLVRLTRHLLSPERYDVRVRPILDHKKSLKVHISISLYQIIEVDEPSQNIKLNVWMIQKWR 110

  Fly    83 DYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNN---------------ADGNYEVTIMTKAILH 132
            |..|.|||::||.:::..:|..|:|:||..|||:               |..||
 Worm   111 DEYLDWNPNEYGMINSTIIPFHHLWIPDTYLYNSVKMSRDETERYMNIQATSNY----------- 164

  Fly   133 HTGKVVWKP----------PAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTAD 187
                  ||.          ||||...|.:::.:||:|.|.|.:...|||.....:|     ..||
 Worm   165 ------WKGEKGAELSFLYPAIYTITCRLNIRFFPYDRQNCTLTISSWTNSKSALD-----YYAD 218

  Fly   188 SDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCV 252
            ::     :.:|.:..:.||.:......|:|..|:||.||::.:..:|.::||.|:|.||||||..
 Worm   219 TE-----VSMQSFIPNEEWQVKSFKIHRHEYKYACCAEPWVILQASLVIQRKPLYYLVNLIIPTS 278

  Fly   253 GISFLSVLVFYLPS----DSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMML 313
            .|:.:::..|:.|:    |..|||:|.|:.||::::..|::::.:|.||..|||:..:.|..:::
 Worm   279 IITLVAITGFFTPASTDDDRTEKINLGITTLLAMSILMLMVSDQMPTTSEFVPLIAWFYLSIIII 343

  Fly   314 VTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHL 378
            :::...:|..||:|..|.........:::.:|..:||::|.:          :.||.:.|....|
 Worm   344 ISIGTFLTSVVLSVQGRRQYGRNPPQFIRYIFFVLLPQVLLL----------NVPPPLQTLWGEL 398

  Fly   379 PPD------------VDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLP 431
            ..|            :.:.||..|.:.:.......:|.|       ||.:|....:...:
 Worm   399 DDDPLNVRRRKKSHYLSRNVNNGSTKMASPMSTLRVPQS-------AGSVSEKRQSFQMI----- 451

  Fly   432 LPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEG-----------SR 485
                  |:.||:.          |..|.:.|..|:|:..|  |...|.|:..           |.
 Worm   452 ------DVTSPNS----------PNTARSRAPSLAPSTAK--ATMWEGTMSALAGTNTQLRRTSN 498

  Fly   486 FIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTA-LIILQAPSLYDQSQPIDILYS 549
            ...:.|....:......:|:::|.||||..|.:|..|.|:.|| ||::...:.|....|.|..::
 Worm   499 VFNKEVDEMRRKRQCSLEWEFLATVLDRFLLIVFVGAVVIVTAGLILVGRMAQYSYDHPDDRFFN 563

  Fly   550  549
             Worm   564  563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	69/244 (28%)
		LIC	27..530	CDD:455710	144/557 (26%)
		Cys-loop	149..163	CDD:349832	5/13 (38%)
deg-3	NP_001379138.1	Neur_chan_LBD	53..266	CDD:460752	68/239 (28%)
		LGIC_TM_cation	267..>357	CDD:349853	30/89 (34%)
		TM1 helix	267..291	CDD:349853	10/23 (43%)
		Neur_chan_memb	273..543	CDD:460753	71/309 (23%)
		TM2 helix	303..324	CDD:349853	5/20 (25%)
		TM3 helix	335..357	CDD:349853	4/21 (19%)