DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and ZACN

DIOPT Version :10

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_851321.2 Gene:ZACN / 353174 HGNCID:29504 Length:412 Species:Homo sapiens


Alignment Length:343 Identity:68/343 - (19%)
Similarity:131/343 - (38%) Gaps:73/343 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 NNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLP 109
            |.|..|.|.:.:.:|.:.:|::....|::.:.:...|.|.:|.||...:.. ..:.:|.|.:|.|
Human    55 NGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTP 118

  Fly   110 DIVLYN---------------NADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFD 159
            .:.:..               :.||:.::.:   |:...|.             |..::.:||.|
Human   119 RLTILEALWVDWRDQSPQARVDQDGHVKLNL---ALATETN-------------CNFELLHFPRD 167

  Fly   160 EQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCE 224
            ...|.:.|       |.:           .|..:.::.|.:.::....:.|...|.:.|    .:
Human   168 HSNCSLSF-------YAL-----------SNTAMELEFQAHVVNEIVSVKREYVVYDLK----TQ 210

  Fly   225 EPYLDIV--FNLTLRRK--TLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVF 285
            .|...:|  |.:|||.|  .|...:.|::|...:....|....||..:.|:|...:::|||..|.
Human   211 VPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVL 275

  Fly   286 FLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILP 350
            ...|.:.:|.:|...|||..|....::|:.||.:.|:.:..:..|..:..:..|           
Human   276 HSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGP----------- 329

  Fly   351 KLLCIERPKKEEPEEDQP 368
                ...|:.|:.|...|
Human   330 ----SPAPRGEQREHGNP 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 LGIC_ECD_nAChR_proto_alpha-like 24..242 CDD:349832 39/215 (18%)
LIC 27..530 CDD:455710 68/343 (20%)
Cys-loop 149..163 CDD:349832 4/13 (31%)
ZACNNP_851321.2 LGIC_ECD_ZAC 60..229 CDD:349795 37/207 (18%)
Cys-loop 157..171 CDD:349795 4/13 (31%)
LGIC_TM 231..407 CDD:476813 29/128 (23%)
TM1 helix 235..255 CDD:349850 3/19 (16%)
TM2 helix 263..284 CDD:349850 5/20 (25%)
TM3 helix 295..317 CDD:349850 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..360 5/31 (16%)
TM4 helix 365..386 CDD:349850
Blue background indicates that the domain is not in the aligned region.

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