Protein Alignment nAChRalpha1 and nAChRbeta3

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_525098.1
• Gene: nAChRbeta3 / 33228
• FlyBaseID: FBgn0031261
• Length: 441
• Species: Drosophila melanogaster
• Alignment Length: 538
• Identity: 124/538 - (23%)
• Similarity: 215/538 - (39%)
• Gaps: 133/538 - (24%)

  Fly     1 MGSVLFAAVFIALHFATGGLANPDAK---RLYDDLLSNYNRLIRPVGNNS-DRLTVKMGLRLSQL 61
            ||.:|.....:....||....|.:.|   ||:..|.:||:..::||...: ..::::|   :...
  Fly    24 MGMLLMGLTSVPGATATADPKNANVKALDRLHAGLFTNYDSDVQPVFQGTPTNVSLEM---VVTY 85

  Fly    62 IDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIM 126
            ||::..|..:||:.|:...|.|.:..|.|..|..:..:.:.|..:|.|.|.|:|..:|.  :...
  Fly    86 IDIDELNGKLTTHCWLNLRWRDEERVWQPSQYDNITQITLKSSEVWTPQITLFNGDEGG--LMAE 148

  Fly   127 TKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI 191
            |:..|.|.|...|.|||:|.::||:::..:|.|:|:|.:|.|||   |..|.|.. ..||..::
  Fly   149 TQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPE-NGTARGES- 208

  Fly   192 EVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISF 256
               :|..|...|.||:|:      :.:.:...::.|..:.:.||.:|::..||..:..|...|..
  Fly   209 ---LDHDDLVQSPEWEIV------DSRAHFVSQDYYGYMEYTLTAQRRSSMYTAVIYTPASCIVI 264

  Fly   257 LSVLVFYLPSD-SGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            |::..|:||.. .||||.:...:::.:..|.:..|:::|..|...||:..:...:::.:::|.:|
  Fly   265 LALSAFWLPPHMGGEKIMINGLLIIVIAAFLMYFAQLLPVLSNNTPLVVIFYSTSLLYLSVSTIV 329

  Fly   321 TIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKF 385
            .:.||   :.:...|:     :||                        ||.|..:.|
  Fly   330 EVLVL---YLATGKHK-----RRL------------------------PEALRKLLH-------- 354

  Fly   386 VNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDIS 450
                     |..|...|.:.    .:..|...|....|   ....|...||:...||.|:|....
  Fly   355 ---------GHLGTWLLLSV----FSTTGESQAEKTKE---MDEHPYEEADEQESSPLGINHTEV 403

  Fly   451 PGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRM- 514
            ||.                            :.::|                ||..:|..:||:
  Fly   404 PGA----------------------------KANQF----------------DWALLATAVDRIS 424

  Fly   515 -------FLWIFAIACVV 525
                   || |.||.|.|
  Fly   425 FVSFSLAFL-ILAIRCSV 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	61/221 (28%)
		LIC	27..530	CDD:455710	117/509 (23%)
		Cys-loop	149..163	CDD:349832	5/13 (38%)
nAChRbeta3	NP_525098.1	LIC	39..437	CDD:455710	117/517 (23%)