Protein Alignment nAChRalpha1 and Chrna7

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_063137740.1
• Gene: Chrna7 / 25302
• RGDID: 2348
• Length: 531
• Species: Rattus norvegicus
• Alignment Length: 567
• Identity: 202/567 - (35%)
• Similarity: 299/567 - (52%)
• Gaps: 77/567 - (13%)

  Fly     2 GSVLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNL 66
            |.:..|.....||.:   |.....:|||.:|:.|||.|.|||.|:|..|||...|.|.|::||:.
  Rat     6 GGIWLALAAALLHVS---LQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDE 67

  Fly    67 KNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYN---------------- 115
            |||::|||:|::..|.|:.|:||..:|.||..:..|...||.|||:|||
  Rat    68 KNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSGCQLHFDQDLQNMLL 132

  Fly   116 -------------NADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKF 167
                         :||..::.|..|..:::.:|...:.||.|:||.|.|||.:||||.|.|.:||
  Rat   133 REACAQAGEDLRVSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKF 197

  Fly   168 GSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVF 232
            |||:|.|:.:||:  .|.|         |:..|..:.|||:|.:|..||||||.||:|||.|:.:
  Rat   198 GSWSYGGWSLDLQ--MQEA---------DISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTY 251

  Fly   233 NLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTS 297
            .:|:||:||:|.:||:||||.||.|::|||.||:||||||||.|::|||||||.||:|||:|.||
  Rat   252 TVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATS 316

  Fly   298 LTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEE 362
            .:|||:.:|...||::|.||||||:.||..:...|...:|..|.:.:.:......|.::||.::
  Rat   317 DSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGED- 380

  Fly   363 PEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLP 427
                   :|.....|.|    :..:..|...|...|.|....:..: :...|....||   .|.|
  Rat   381 -------KVRPACQHKP----RRCSLASVELSAGAGPPTSNGNLLY-IGFRGLEGMHC---APTP 430

  Fly   428 SSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVK 492
            .|..:.|               ...|.|...........|:...|   ::.|.:|..|:||...:
  Rat   431 DSGVVCG---------------RLACSPTHDEHLMHGAHPSDGDP---DLAKILEEVRYIANRFR 477

  Fly   493 NKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYD 539
            .:|:.|.:..:||:.|.|:||:.|..|::..::.|..|::.||:..:
  Rat   478 CQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVE 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	99/246 (40%)
		LIC	27..530	CDD:455710	194/531 (37%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
Chrna7	XP_063137740.1	None