DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha1 and GABRR3

DIOPT Version :10

Sequence 1:NP_001262916.1 Gene:nAChRalpha1 / 42918 FlyBaseID:FBgn0000036 Length:597 Species:Drosophila melanogaster
Sequence 2:NP_001099050.1 Gene:GABRR3 / 200959 HGNCID:17969 Length:467 Species:Homo sapiens


Alignment Length:319 Identity:73/319 - (22%)
Similarity:132/319 - (41%) Gaps:30/319 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 YDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPD 91
            |:.||  .:.:..:|| |.....:.|.:.:.:..:..::..|...|...::...|.|.:|.:...
Human    61 YEQLLHIEDNDFAMRP-GFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPST 124

  Fly    92 DYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAIL--HHTGKVVWKPPAIYKSFCEIDVE 154
            ....:...|..:..||:|||...::.......|.|...:|  |..|.|:........:.|.:|..
Human   125 ANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFS 189

  Fly   155 YFPFDEQTCFMKFGSWTY--DGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNE 217
            .||.|.|.|.::..|:.|  |..|:..:|..:   |.|.|..:.|..::|.      ...|....
Human   190 RFPLDTQNCSLELESYAYNEDDLMLYWKHGNK---SLNTEEHMSLSQFFIE------DFSASSGL 245

  Fly   218 KFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYL-----PSDSGEKISLCIS 277
            .|||.... |..:..|..|||...|:.:....|.:.:..||.:.|::     |:    ::||.|:
Human   246 AFYSSTGW-YNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPA----RVSLGIT 305

  Fly   278 ILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHR 336
            .:|:::.....::..:|..|. :..:..||..:.:.|.|||:...|   ||:.:.|..|
Human   306 TVLTMSTIITAVSASMPQVSY-LKAVDVYLWVSSLFVFLSVIEYAA---VNYLTTVEER 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha1NP_001262916.1 LGIC_ECD_nAChR_proto_alpha-like 24..242 CDD:349832 50/218 (23%)
LIC 27..530 CDD:455710 73/319 (23%)
Cys-loop 149..163 CDD:349832 6/13 (46%)
GABRR3NP_001099050.1 LIC 55..466 CDD:455710 73/319 (23%)
LGIC_ECD_GABAAR_rho 82..267 CDD:349806 44/194 (23%)
Cys-loop 184..198 CDD:349806 6/13 (46%)
Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:P50573 347..448 5/17 (29%)

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