Protein Alignment nAChRalpha1 and acr-11

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_491906.1
• Gene: acr-11 / 191599
• WormBaseID: WBGene00000050
• Length: 461
• Species: Caenorhabditis elegans
• Alignment Length: 536
• Identity: 185/536 - (34%)
• Similarity: 278/536 - (51%)
• Gaps: 88/536 - (16%)

  Fly     5 LFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQ 69
            :.:.|.|..:...|.:|.   .:|:.|||..||.|.|||.|:|..|.||:.|.|.|::||:.|||
 Worm     9 ILSLVIIHSNLCDGSVAE---TKLFTDLLKGYNPLERPVQNSSQPLEVKIKLFLQQILDVDEKNQ 70

  Fly    70 IMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVP--SEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            |::.|.|:...|.|:||:|.|..|||:..:..|  |:|||.||::|||:|..:::.|..:..:.:
 Worm    71 IVSVNAWLSYTWFDHKLQWEPKKYGGIQDIRFPGSSDHIWKPDVLLYNSAAEDFDSTFKSNLLTY 135

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197
            |||.|||.||.:.|..|::||.:||||:|.|.|||||||:.||.:||    |..|..|....:||
 Worm   136 HTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDL----QIDDDTNGTQSMDL 196

  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262
            ..|.::.||.::...|.|...:|.||.|||..:.:.|.:||:||:|..|||||.:.||.:::|.|
 Worm   197 STYLVNGEWQVISTNAKRVVSYYKCCPEPYPTVNYYLHIRRRTLYYGFNLIIPSLLISLMAILGF 261

  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNV 327
            ..|.|:||||:|.::|||::..|..:::|:.||||..|||:|.:....|::|:.|||.||.|||:
 Worm   262 MFPPDAGEKITLEVTILLAIVFFLSMVSEMTPPTSEAVPLIGVFFSCCMLVVSASVVFTIVVLNL 326

  Fly   328 NFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKR 392
            :|||..:|.|.|.|:|:.::.||.||.:.||..                       |||.  :..
 Worm   327 HFRSADSHEMNPLVRRVLLEFLPWLLFMSRPGY-----------------------KFVK--ANV 366

  Fly   393 FSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAA 457
            ......:|..|.:                   ||..:||...|.
 Worm   367 IDSTDKMPKKPKN-------------------PLDCNLPSNHAG--------------------- 391

  Fly   458 AAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKF-ESVEEDWKYVAMVLDRMFLWIFAI 521
                       :|...........|..|.:|.:  ||::. |.::.||::.|||:||..|.:|.:
 Worm   392 -----------YEAQILLLHSVHTELRRVVAFY--NKEEHDERIQTDWRFAAMVVDRACLLLFTV 443

  Fly   522 ACVVGTALIILQAPSL 537
            ..|:....|::.||.:
 Worm   444 FIVISILAIMMSAPHI 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	96/219 (44%)
		LIC	27..530	CDD:455710	178/505 (35%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
acr-11	NP_491906.1	LIC	25..456	CDD:455710	180/515 (35%)
		LGIC_ECD_nAChR	51..238	CDD:349798	82/190 (43%)
		Cys-loop	152..166	CDD:349798	8/13 (62%)