Protein Alignment nAChRalpha1 and lgc-1

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_504154.5
• Gene: lgc-1 / 188099
• WormBaseID: WBGene00020236
• Length: 371
• Species: Caenorhabditis elegans
• Alignment Length: 371
• Identity: 89/371 - (23%)
• Similarity: 171/371 - (46%)
• Gaps: 81/371 - (21%)

  Fly    24 DAKRLYDDLLSNYNRLIRPVG--------NNSDRL-----TVKMGLRLSQLIDVNLKNQIMTTNV 75
            |.|||:|||..:|:..:..:.        |.:..:     .:|:.:.:.:|:||          |
 Worm    15 DQKRLWDDLFKDYDPTLSAIYTLHKSQWINQTATIHPPITELKLTMAMLKLVDV----------V 69

  Fly    76 WVEQ----------EWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTK-- 128
            .||:          ||.|.:|||||.:|||:..::||...||||::.:   ||. :||.....
 Worm    70 EVEEKVTFLFDYLAEWTDQRLKWNPLEYGGISHIYVPQRMIWLPEVTI---ADA-HEVKFFESDD 130

  Fly   129 ----AILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMK--FGSWTYDGYMV--DLRHLKQT 185
                |.:::.|...:....:....|::||..||.|...|.:.  |.::..|.|::  |:..|.:.
 Worm   131 APRTAWINYNGTTGFYTSTVSSVICQLDVYKFPLDRHECGVSVLFHTYFADEYVIKSDMEPLPKP 195

  Fly   186 ADSDNIEVGIDLQDYYISVEWDIMRV---PAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNL 247
            ..    ::|        :.||.:..:   ..:.|..| |..:.      |...:.|...||...:
 Worm   196 LS----QLG--------NGEWKVTYIGVAEEIGNGNF-SAVQR------FVARIERNPGFYVTLV 241

  Fly   248 IIPCVGISFLSVLVFYLPSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTM 311
            ::|...|:|||::...|..:: ||||::.::.::::|...::||:.:|.|. .:|||..|::..:
 Worm   242 MVPAFFINFLSIIALCLNIENVGEKITVGLTNIMAMTFILVILAQDLPKTK-RIPLLAIYVIVGL 305

  Fly   312 MLV--TLSVVVTIAVLNVNFR--------SPVTHRMAPWVQRLFIQ 347
            ::|  ::.||:|:.::..:.:        .||..|.:.|...|.::
 Worm   306 VIVMASIGVVLTLPLIRNHLKKRQKGKEEKPVETRFSKWFGWLTVE 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	59/253 (23%)
		LIC	27..530	CDD:455710	87/368 (24%)
		Cys-loop	149..163	CDD:349832	6/13 (46%)
lgc-1	NP_504154.5	LIC	84..>335	CDD:455710	68/274 (25%)