Protein Alignment nAChRalpha1 and lgc-30

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_500015.3
• Gene: lgc-30 / 186551
• WormBaseID: WBGene00019069
• Length: 529
• Species: Caenorhabditis elegans
• Alignment Length: 418
• Identity: 116/418 - (27%)
• Similarity: 196/418 - (46%)
• Gaps: 59/418 - (14%)

  Fly    12 ALHFATGG--LANPDAK-----RLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQ 69
            ||....||  :|:|||.     ||...:.|:....| |:.:...|:.|.:...|.|::|::.:|.
 Worm    46 ALDKEDGGQVIADPDADGDPHGRLATWIRSHARHHI-PLKHPHTRIDVFISAGLYQIVDLDQRNN 109

  Fly    70 IMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNY-EVTIMTKAILHH 133
            :.|.:.:::..|||..:||.|:.:||::.:.||.:.||.|:..:|::..|.. :......|.||:
 Worm   110 LATVSAYLDVHWNDDFIKWKPEIFGGIERIFVPIKWIWKPEFYMYHSVYGRVPDYAPDASAELHY 174

  Fly   134 TGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQ 198
            .|.|........||||.|:.:.||||.|||....|||.|...:|:|...||.         |.|:
 Worm   175 NGLVRMFVSISSKSFCPINFKRFPFDSQTCSFSCGSWAYQSNIVNLVAAKQE---------IALE 230

  Fly   199 DYYISVEWDIMRV----PAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSV 259
            |:|.:.||.:...    ...||   .|...|.:..:...|.|:|::.:|..||:.|...:|.::|
 Worm   231 DFYDNQEWLLTDARLFNGTTRN---VSAANESFSMVYMQLDLKRQSFYYVFNLVFPTTLVSLVAV 292

  Fly   260 LVFYLPSDS----GEKISLCISILLSLTVFFLLLA-------EIIP---PTSLTVPLLGKYLLFT 310
            :.|:.|.::    ..|..|.|..|||::|..|:|.       |.:|   .:...|||:|.|.:..
 Worm   293 IGFHAPINATGRRESKFRLGIMTLLSMSVMLLMLVGEMKFAMESVPGQRGSFSDVPLMGIYYMTL 357

  Fly   311 MMLVTLSVVVTIAVLNVN---FRSPVTHRMAPWVQRLFIQIL--PKLLCIERPKKEEPEED---Q 367
            :.:|:::...:...:::.   .|:| :.:..||    :|:.|  .||.|...||....::|   :
 Worm   358 ICIVSIATCTSSIFVHLEKFALRNP-SWQSVPW----YIRWLAAKKLFCCYVPKSFRYDKDAYSR 417

  Fly   368 PPEVLTDVYHLPPD-------VDKFVNY 388
            ...|.....|..||       :.|.:|:
 Worm   418 NNNVQAISLHSTPDRNVAKNLIPKEINF 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	67/227 (30%)
		LIC	27..530	CDD:455710	108/396 (27%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:460752	64/216 (30%)
		LGIC_TM_cation	274..>374	CDD:349853	25/99 (25%)
		TM1 helix	274..298	CDD:349853	7/23 (30%)
		TM2 helix	310..338	CDD:349853	9/27 (33%)
		TM3 helix	352..374	CDD:349853	2/21 (10%)