Protein Alignment nAChRalpha1 and lgc-6

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_501410.3
• Gene: lgc-6 / 184621
• WormBaseID: WBGene00017544
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 313
• Identity: 70/313 - (22%)
• Similarity: 154/313 - (49%)
• Gaps: 48/313 - (15%)

  Fly    45 NNSDRLTVKMGLRLSQLIDVNLKNQ------IMTTNVWV------EQE-----------WNDYKL 86
            :|::.|..::   .:|..||::|..      .:|.|.::      .||           |.|..|
 Worm    17 SNTETLLQQL---FNQTYDVDMKPSDDLTMVTITPNTFILLSMDQTQETIQYSEEFLLRWYDPIL 78

  Fly    87 KWNPD--DYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTK----AILHHTGKVVWKPPAIY 145
            .||..  .|.. |.:.:.:...|:||::..|..|.:   .::.|    |.|.:.|::....||:.
 Worm    79 HWNQSAVSYEN-DWIKISASRAWIPDVIFTNGIDMD---PLLDKDMQMADLRYNGEIRTSRPAVV 139

  Fly   146 KSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMR 210
            .|.|.::::.||:|.|.|.:..|||.:|...:.::       |..||:......:..:.||:::.
 Worm   140 SSPCPLEIDNFPYDVQKCNISMGSWAFDRRFLSVQ-------SSTIEILPQKGRFEGNSEWELIS 197

  Fly   211 VPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGE----K 271
            :..||::.:.:..||.:.:|.:.:||:||.::|.:.:..|...:..:::...:.|:.:.:    |
 Worm   198 ILTVRSDSYDTLLEEWFSEITYVVTLKRKPVYYVLVIQAPTFILCTITIFGLFTPNSNEDERLSK 262

  Fly   272 ISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAV 324
            :.||:::..::::...|:::::|..| .:||||.|::..:.:||.:.:.:|.:
 Worm   263 VELCLNMFAAISMMLQLVSDMMPKAS-RLPLLGNYIIAEIFVVTAATIASIII 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	53/225 (24%)
		LIC	27..530	CDD:455710	70/313 (22%)
		Cys-loop	149..163	CDD:349832	5/13 (38%)
lgc-6	NP_501410.3	LIC	1..424	CDD:455710	70/313 (22%)
		LGIC_ECD_cation	42..226	CDD:349790	45/194 (23%)
		Cys-loop	143..157	CDD:349790	5/13 (38%)