Protein Alignment nAChRalpha1 and lgc-5

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_501411.4
• Gene: lgc-5 / 184620
• WormBaseID: WBGene00017543
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 391
• Identity: 83/391 - (21%)
• Similarity: 177/391 - (45%)
• Gaps: 65/391 - (16%)

  Fly    39 LIRPVGNNSDRLTVKMGLRLSQLI----DVNLKNQIMTTNVWV-------------------EQE 80
            ::|..|:|:..:.....:.|.:|.    |||:|.....|.|.:                   .||
 Worm    13 VLRTFGSNTTNVESNTEVLLQELFNRTYDVNVKPSDTLTTVTITPNTFLLLSMDQTQETILFSQE 77

  Fly    81 ----WNDYKLKWNPD--DYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTI---MTKAILHHTGK 136
                |.|..|.||..  ||.. :.:.:....:|:||::.....  :.|..:   |..|.|.:.|:
 Worm    78 FLLKWYDPILHWNRTLFDYNR-EWIKISVSRVWVPDVIFTKRL--SVESLLDEDMQMADLRYNGE 139

  Fly   137 VVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYY 201
            :....||:..:.|.::::.||.|.|.|.:..|||.:|..::.::        .:::..:.|:..:
 Worm   140 IRTSLPAVVSTSCPLNIQDFPHDVQECNISMGSWAFDRTVIVVQ--------SSVDEILPLRGRF 196

  Fly   202 I-SVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLP 265
            . :.||:::.:.|.|.:.|.......:.:|.:.:||:||.::|.:.:..|...:..:::...:.|
 Worm   197 EGNSEWELLSIRAFRTDSFEYSLGTSFSEITYTVTLQRKPVYYVLVIQAPTFILCTITIFGLFSP 261

  Fly   266 -SDSGEKIS---LCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLN 326
             |:..|::|   ||:::..::::...|:::::|..| .:||||.|::..:.:||.:.:..|.:.:
 Worm   262 NSNENERLSRVELCLNMFAAISMMLQLVSDMMPKAS-RLPLLGNYIIAEIFVVTAATIAAIVIQH 325

  Fly   327 VNFRSPVTHRMAP-WVQRLFIQILPKLLCIERPKKEEPEE-------DQPPEVLTDVYHLPPDVD 383
            |:..........| |::.|       :|| :..::|.|.:       |.|..::..|..|...:.
 Worm   326 VHHHVHTNATCPPKWLRCL-------VLC-DCMREEFPSKTSSVSSMDVPENIIAPVSLLKSSLH 382

  Fly   384 K 384
            |
 Worm   383 K 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	51/235 (22%)
		LIC	27..530	CDD:455710	83/391 (21%)
		Cys-loop	149..163	CDD:349832	5/13 (38%)
lgc-5	NP_501411.4	LGIC_ECD_cation	51..235	CDD:349790	40/194 (21%)
		Cys-loop	152..166	CDD:349790	5/13 (38%)
		LGIC_TM	238..>323	CDD:476813	19/85 (22%)
		TM1 helix	241..261	CDD:349853	1/19 (5%)
		TM2 helix	273..294	CDD:349853	3/20 (15%)
		TM3 helix	304..323	CDD:349853	4/18 (22%)