Protein Alignment nAChRalpha1 and nAChRbeta2

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_061506567.1
• Gene: nAChRbeta2 / 1272992
• VectorBaseID: AGAMI1_002531
• Length: 530
• Species: Anopheles gambiae
• Alignment Length: 538
• Identity: 306/538 - (56%)
• Similarity: 389/538 - (72%)
• Gaps: 61/538 - (11%)

  Fly    21 ANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYK 85
            |||||||||||||||||||||||.||::.|||.:||:|||||:|:|:||:||||:||:|:|.|||
Mosquito    36 ANPDAKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVSLRNQVMTTNLWVKQKWFDYK 100

  Fly    86 LKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCE 150
            |:|:|::||||:.|:||||.|||||||||||.|||||||:||||.|.:||:|.|:|||||||.||
Mosquito   101 LRWDPEEYGGVEMLYVPSEQIWLPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCE 165

  Fly   151 IDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVR 215
            ::|||||:|||||.||||||||:|..|:||||.|...|:.:::||||.::|:||||||:.|||.|
Mosquito   166 MNVEYFPYDEQTCLMKFGSWTYNGAQVELRHLDQIPGSNLVQIGIDLSEFYLSVEWDILEVPASR 230

  Fly   216 NEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILL 280
            ||::|.||.||:.||.|.||:||||||||||||||||||:||:|||||||||||||::||||||:
Mosquito   231 NEEYYPCCPEPFSDITFKLTMRRKTLFYTVNLIIPCVGITFLTVLVFYLPSDSGEKVTLCISILV 295

  Fly   281 SLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLF 345
            ||||||||||||||||||.||||||||||||:||:|||..|:.||||.:||..||:|:|:|:|||
Mosquito   296 SLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNVWYRSTSTHKMSPFVRRLF 360

  Fly   346 IQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDL 410
            ::|:||:|.:.|.|                |.||       :||....|..|       ::..::
Mosquito   361 LEIMPKILMMRRAK----------------YTLP-------DYDDSTPSNGY-------TNEIEM 395

  Fly   411 AAAGGISAHCFAEPPLPSSLPLPG---ADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKP 472
            :.:                 ..||   ...|.|...|:|  :|.|      :..|.::.|   |.
Mosquito   396 SVS-----------------DFPGEFKEGGDSFDNIGVN--LSHG------SVEAENVIP---KQ 432

  Fly   473 YAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSL 537
            .:.|:...|:..||||||:|:.||...:.||||:|:|||||.|||:|.|:|:.||..||.|:|||
Mosquito   433 LSPEVLSAIQAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWVFTISCIFGTFGIIFQSPSL 497

  Fly   538 YDQSQPIDILYSKIAKKK 555
            ||...|:|...|:|..:|
Mosquito   498 YDTRAPVDQQLSEIPLRK 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	152/217 (70%)
		LIC	27..530	CDD:455710	287/505 (57%)
		Cys-loop	149..163	CDD:349832	10/13 (77%)
nAChRbeta2	XP_061506567.1	None