Protein Alignment nAChRalpha1 and LOC116410385

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_031756604.1
• Gene: LOC116410385 / 116410385
• XenbaseID: XB-GENE-29096091
• Length: 456
• Species: Xenopus tropicalis
• Alignment Length: 508
• Identity: 112/508 - (22%)
• Similarity: 210/508 - (41%)
• Gaps: 114/508 - (22%)

  Fly    40 IRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSE 104
            :||....:||..|.:.|.|..:||::::.||:||.:|....|.:..:.|:.:.|.|::.:.|...
 Frog    42 VRPTMVWTDRTNVTLDLALYSIIDLDMQQQIITTYIWFSMSWKNDFVNWDSNTYCGIEKVVVSDT 106

  Fly   105 HIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGS 169
            .:|.||:.:|...|.:.:...:....:::.|.|....|......|.:....||||||.|.:.|||
 Frog   107 LVWRPDLYIYEMVDDDDKSPKINYLKIYYNGIVTNSKPLRIAGSCSMQNFKFPFDEQNCSLTFGS 171

  Fly   170 WTYDGYMVDLRHLKQTADSDNIEVGIDLQDYY-ISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFN 233
            :.|:.:.|.:     .|.|::.:|..:.:|.: ...:|.::.: .|||....|   ..:..:.:.
 Frog   172 YVYNDFEVYM-----MAASNSSQVTENSKDIFRTKGDWILLNI-IVRNNPLPS---GNFNRVTYE 227

  Fly   234 LTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSL 298
            :.::|..:.|..|||:|...:..|.:...::....| :::..::|:|..:|..|:|:.:: |.|.
 Frog   228 IHIKRNPIIYVFNLILPACFLVILDIASMFMEGTEG-RLTFKVTIVLGFSVLLLILSGML-PNSD 290

  Fly   299 TVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAP-WVQRLFIQILPKLLCIERPKKEE 362
            |.|:||.:....|:::.||:...|.  .|:.|:.......| |:::..|..|..:||.|....:|
 Frog   291 TPPMLGIFFSVCMIMMVLSIGGCIC--TVSMRTKCATASVPLWIKKWIIGYLACVLCYETKFIKE 353

  Fly   363 P-----------EEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGI 416
            .           |.||.|            .:|....:.:|...|
 Frog   354 HLVKVVSRIHTCEHDQKP------------TNKIEVEEKRRNLAD-------------------- 386

  Fly   417 SAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTI 481
                  |.|:.:|:.:                                            :.|.:
 Frog   387 ------EDPITTSVQI--------------------------------------------LNKML 401

  Fly   482 EGSRFIAQHV---KNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALII 531
            .|.:.|...:   |:||. .|:|  :...||||||.||.|:.|..::.|:::|
 Frog   402 VGIKKIHHEIAVSKHKDD-SSLE--FYIAAMVLDRFFLIIYLITVIITTSIMI 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	50/202 (25%)
		LIC	27..530	CDD:455710	111/505 (22%)
		Cys-loop	149..163	CDD:349832	7/13 (54%)
LOC116410385	XP_031756604.1	LGIC_ECD	23..233	CDD:475126	49/199 (25%)
		LGIC_TM	235..>319	CDD:476813	23/87 (26%)
		TM1 helix	239..259	CDD:349850	5/19 (26%)
		TM2 helix	266..287	CDD:349850	5/21 (24%)
		TM3 helix	297..319	CDD:349850	5/23 (22%)