Protein Alignment nAChRalpha1 and Chrng

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_006529141.1
• Gene: Chrng / 11449
• MGIID: 87895
• Length: 541
• Species: Mus musculus
• Alignment Length: 545
• Identity: 181/545 - (33%)
• Similarity: 275/545 - (50%)
• Gaps: 84/545 - (15%)

  Fly    18 GGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWN 82
            |..:....:||..||:.||:..:||...:||.:.|.:.|.|:.||.:|.:.:.:|||||:|.:|.
Mouse    41 GAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWC 105

  Fly    83 DYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKS 147
            ||:|:|:|.||.|:..|.|||..:|.|||||.||.||.:||.:....::...|.:.|.||||::|
Mouse   106 DYRLRWDPKDYEGLWILRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRS 170

  Fly   148 FCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIE-VGIDLQDYYISVEWDIMRV 211
            .|.|.|.|||||.|.|.:.|.|.||....::|: |.| .|...|| :.||.:.:..:.||.|...
Mouse   171 SCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQ-LSQ-EDGQAIEWIFIDPEAFTENGEWAIRHR 233

  Fly   212 PAVRNEKFYSCCEEP-YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDS-GEKISL 274
            ||.......:..||. :..:||.|.::||.|||.:|:|.|||.||.:::|:::||:.: |:|.::
Mouse   234 PAKMLLDSVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTV 298

  Fly   275 CISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAP 339
            ..::||:.|||..|:|:.:|.||..|||:.|||.|.|::..|.||.::.||||:.|||.||.||.
Mouse   299 ATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMAR 363

  Fly   340 WVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGIPALPA 404
            .|:::|:::||:||.:                     |:.|..                 ||...
Mouse   364 GVRKVFLRLLPQLLRM---------------------HVRPLA-----------------PAAVQ 390

  Fly   405 SHRFDL--AAAGG--ISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDI---------------S 450
            ..||.|  .::.|  |.|....:..||.|       :.||.....||.:               |
Mouse   391 DARFRLQNGSSSGWPIMAREEGDLCLPRS-------ELLFRQRQRNGLVQAVLEKLENGPEVRQS 448

  Fly   451 PGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMF 515
            ...|.:...|:.|             ::..::....:|:..:.:..|:|..|:|..|..||||:.
Mouse   449 QEFCGSLKQASPA-------------IQACVDACNLMARARRQQSHFDSGNEEWLLVGRVLDRVC 500

  Fly   516 LWIFAIACVVGTALIILQAPSLYDQ 540
            ........:.|||.|.|.|.  |:|
Mouse   501 FLAMLSLFICGTAGIFLMAH--YNQ 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	88/219 (40%)
		LIC	27..530	CDD:455710	175/524 (33%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
Chrng	XP_006529141.1	LGIC_ECD_nAChR_G	71..263	CDD:349830	78/193 (40%)
		Cys-loop	172..186	CDD:349830	9/13 (69%)
		Neur_chan_memb	270..516	CDD:460753	83/303 (27%)