Protein Alignment nAChRalpha1 and htr3a

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_031762490.1
• Gene: htr3a / 101731577
• XenbaseID: XB-GENE-990708
• Length: 474
• Species: Xenopus tropicalis
• Alignment Length: 534
• Identity: 130/534 - (24%)
• Similarity: 243/534 - (45%)
• Gaps: 88/534 - (16%)

  Fly     4 VLFAAVFIALHFATGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKN 68
            ||..::.|..:......:.|...||.|.|:..|.:.:|||.:.....||.:.:.:..::.|:.||
 Frog    12 VLILSLLIPCYANVNRSSKPTLLRLSDHLMEGYKKGVRPVLDWRQTTTVYIDVMVYAILGVDEKN 76

  Fly    69 QIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHH 133
            |::||.:|..|.|.|..|.|:|..:..|..:.:|:|.||:|||::....|......| ....::|
 Frog    77 QVLTTYIWYRQFWVDEFLTWDPKKFENVSQISIPTEKIWVPDILINEFVDVGKSPDI-PYVYVNH 140

  Fly   134 TGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNI------- 191
            .|:|....|....:.|.:::..||||.|.|.:.|.||.:            |....|:
 Frog   141 EGRVQNYKPIQVVTACSLNIYNFPFDVQNCSLTFTSWLH------------TIQDINVSLWRTPE 193

  Fly   192 EVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISF 256
            ||..|...:..:.||:::.|.: :..||.. .|:.:.::.|::.::|:.|||.|||::|.:.:..
 Frog   194 EVKEDKSLFMNNGEWELLSVLS-QYRKFVE-NEDSFAEMKFHVVIKRRPLFYAVNLLLPSMFLMV 256

  Fly   257 LSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVT 321
            :.::.||||.||||::|..|::||..:||.:::::.:|.|::..||:|.|.:..|.|:.:|:..|
 Frog   257 MDIIGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLTET 321

  Fly   322 IAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFV 386
            |.::.:..:..:...:..|::||.::.:..||||.
 Frog   322 ILIVRLVHKQDLQTHVPEWLKRLVLEKITALLCIR------------------------------ 356

  Fly   387 NYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISP 451
              |.|:| |...:.:...||:.:.::...: ||...|.|           .|.....|:
 Frog   357 --DKKKF-GAVRVHSSDISHQMENSSTAKL-AHYSTEYP-----------KDYERSVGV------ 400

  Fly   452 GCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFL 516
                         |.|:.|.|..  ::..:.....|.|:::.:|:...:.::|..|..|||.:..
 Frog   401 -------------LVPSKENPLV--VDNILHEIASIRQYLEKRDQCRDIAKEWLQVGYVLDILLF 450

  Fly   517 WIFAIACVVGTALI 530
            .|:.:|.:..|..:
 Frog   451 RIYLVAMLAYTVTL 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	60/224 (27%)
		LIC	27..530	CDD:455710	126/509 (25%)
		Cys-loop	149..163	CDD:349832	6/13 (46%)
htr3a	XP_031762490.1	LIC	13..468	CDD:455710	129/533 (24%)
		LGIC_ECD_5-HT3A	33..239	CDD:349812	59/220 (27%)
		Cys-loop	156..170	CDD:349812	6/13 (46%)