Protein Alignment nAChRalpha1 and chrna8

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_021329572.1
• Gene: chrna8 / 100537531
• ZFINID: ZDB-GENE-090313-161
• Length: 516
• Species: Danio rerio
• Alignment Length: 559
• Identity: 211/559 - (37%)
• Similarity: 307/559 - (54%)
• Gaps: 82/559 - (14%)

  Fly     4 VLFAAVFIALHFA-TGGLANPDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            :|...:||...|. .|.|.....::||.:|:.|||||.|||.|:|..:.|::||.|.|:|||:.|
Zfish    10 ILHLGIFIWTSFCIKGSLQGEYQRKLYKELMENYNRLERPVLNDSAPIVVELGLTLLQIIDVDEK 74

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            ||::.||.|::..|.|..|.||||:|.||.||..||..||.|||:|||:||..::.|..|..:::
Zfish    75 NQVLITNAWLQLGWTDVYLSWNPDNYPGVQTLRFPSNQIWTPDILLYNSADERFDATFHTNVLVN 139

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197
            .:|...:.||.|.||.|.|||.:||||.|.|.:||||||::|:::||:           ...:|:
Zfish   140 ASGACQYIPPGILKSTCYIDVRWFPFDIQKCDLKFGSWTHNGWLLDLQ-----------MQAVDI 193

  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262
            ..|..:.|||::.||..|||.:|.||:|||.|:.|.:|:||:||:|.:||:||||.||.|::|||
Zfish   194 STYIPNGEWDLVGVPGKRNELYYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISGLALLVF 258

  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNV 327
            .||:||||||||.|::|||||||.||:|||:|.||.:|||:.:|...|||:|.||||||:.||..
Zfish   259 LLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQF 323

  Fly   328 NFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKR 392
            :...|...:|..||:.:.:......|.:::|.:|....                    ..||..
Zfish   324 HHHDPQGGKMPRWVRVILLNWCAWFLRMKKPGEERKAN--------------------FKYDQS- 367

  Fly   393 FSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNG---------D 448
                      ||.|    |:|..|.....  |..|||           :.|..||         .
Zfish   368 ----------PAHH----ASASSIQMGVM--PGQPSS-----------TNSTTNGHMNLYFGYHS 405

  Fly   449 ISPGCCP------AAAAAAAADLSPTFE-----KPYAREME--KTIEGSRFIAQHVKNKDKFESV 500
            |...|||      .:.:......||..|     :.:|.|.|  :.:....:|||..:::|:.|::
Zfish   406 IDSACCPPSSDSGVSCSGGRVGGSPNEEQREGVRMFAGEPEIHRILAEVMYIAQRFRDQDEAEAI 470

  Fly   501 EEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYD 539
            ..:||:.|.|:||:.|..|::..::.|..|::.||:..:
Zfish   471 CSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNFIE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	100/217 (46%)
		LIC	27..530	CDD:455710	202/524 (39%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
chrna8	XP_021329572.1	LIC	12..504	CDD:455710	208/550 (38%)