Protein Alignment nAChRalpha1 and chrnb4

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_012822341.1
• Gene: chrnb4 / 100497893
• XenbaseID: XB-GENE-985370
• Length: 481
• Species: Xenopus tropicalis
• Alignment Length: 526
• Identity: 227/526 - (43%)
• Similarity: 321/526 - (61%)
• Gaps: 78/526 - (14%)

  Fly    26 KRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKW 88
            :||.::||  ..||:||||..|||..:::::.|.|:|||.||.:.||||||||:.|||.||:|.|
 Frog    27 ERLMNNLLRKDKYNKLIRPAYNNSQLVSIQLQLSLAQLISVNEREQIMTTNVWLNQEWVDYRLTW 91

  Fly    89 NPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDV 153
            ||.||.|:..|.:||:.||||||||||||||.|||::.|.||:.:.|.|.|.|||||||.|:|:|
 Frog    92 NPADYDGIKKLRIPSQQIWLPDIVLYNNADGTYEVSLFTNAIVQNNGSVAWLPPAIYKSACKIEV 156

  Fly   154 EYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEK 218
            ::||||:|.|.:||.|||||...:||...|..|..|         |:..|.||||:.:|..|.
 Frog   157 KHFPFDQQNCTLKFRSWTYDYTEIDLVLNKGWATMD---------DFTPSGEWDIIELPGRRT-- 210

  Fly   219 FYSCCEEP-YLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSL 282
              .|..:| |:|:.::..::||.||||:||||||:.|:.|::||||||||.|:|::||||:||:|
 Frog   211 --ICPLDPTYVDVTYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPSDCGQKMTLCISVLLAL 273

  Fly   283 TVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQ 347
            |||.||:::|:|||||.|||:||||:|||:|||.|:|.::.||||:.|||.||.|.|||:..|:.
 Frog   274 TVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMPPWVKNCFLD 338

  Fly   348 ILPKLLCIERPKKEEPEEDQPPEVLTDVYHLPPDVDKFVNYDSKRFSGDYGI---PALPASHRFD 409
            .||..|.::|     ||.....:.|.. |.....::.|.|       .:|.:   .|.|..|..:
 Frog   339 RLPVFLFMKR-----PENSSASQKLRS-YRRNMQIESFRN-------SNYFVNMTTARPCDHTVN 390

  Fly   410 LAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYA 474
                         :||                                .:....:....:.:.|.
 Frog   391 -------------DPP--------------------------------ESVRHQEFRYRYPRKYT 410

  Fly   475 REMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYD 539
            .|:.:.::|.:||::|:|::|:.:|:.|||||||||:||:|||||.|.|:|||..:.:| |.:.:
 Frog   411 PEVHEAMDGVKFISEHMKSEDEDQSIIEDWKYVAMVVDRLFLWIFIIVCIVGTVGLFMQ-PLIQN 474

  Fly   540 QSQPID 545
            .:.|.|
 Frog   475 HTPPDD 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	108/218 (50%)
		LIC	27..530	CDD:455710	223/508 (44%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrnb4	XP_012822341.1	LIC	21..468	CDD:455710	223/511 (44%)
		LGIC_ECD	53..230	CDD:475126	93/189 (49%)