Protein Alignment nAChRalpha1 and chrne

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_002941867.4
• Gene: chrne / 100497712
• XenbaseID: XB-GENE-979686
• Length: 505
• Species: Xenopus tropicalis
• Alignment Length: 550
• Identity: 190/550 - (34%)
• Similarity: 286/550 - (52%)
• Gaps: 83/550 - (15%)

  Fly     4 VLFAAVFIALHFATGGLAN-PDAKRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |.|.::.|.||   ..||| .:..||...|.:||:...||.....|.:.|.:.|.|:.|||:|.|
 Frog     5 VCFLSLLILLH---NSLANESEESRLIKYLFTNYDSKARPSKGIDDVVPVSLKLTLTNLIDLNEK 66

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            .:.:||||||:..|.|.:|.||..:|||:..:.||.:.:|||:|||.||.|||:||......::|
 Frog    67 EETLTTNVWVQIAWQDDRLTWNETEYGGMPLVQVPHDMMWLPEIVLENNIDGNFEVAYYANVLVH 131

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDN----IEV 193
            .||.:.|.||||::|.|.|::.|||||.|.|.:.|.|.||....:|| ||  .||.:.    .:|
 Frog   132 STGYIYWLPPAIFRSTCSIEITYFPFDWQNCSLVFRSKTYSANDIDL-HL--VADDETGLPFDQV 193

  Fly   194 GIDLQDYYISVEWDIMRVPA--VRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISF 256
            .||.:.:..:.||.||..||  :.|.| ||..:..|.:|||.|.::||.|||.:|:|:|||.||.
 Frog   194 DIDREAFTENGEWAIMHRPARKIVNPK-YSKEDLRYQEIVFILIIQRKPLFYIINIIVPCVLISS 257

  Fly   257 LSVLVFYLPSDS-GEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            |.|||::||:.: |:|.::.||:||:.|||..|:|::||.|||:|||:||||:|.|.:.||.|:.
 Frog   258 LVVLVYFLPAKAGGQKCTVSISVLLAQTVFLFLIAQMIPETSLSVPLIGKYLMFVMFVSTLIVLS 322

  Fly   321 TIAVLNVNFRSPVTHRMAPWVQRLFIQILPKLLCIERPKKEEPEEDQPPE---------VLTDVY 376
            .:.||||:.|||.||.::..|:.:.:::||:.:.:.....:|.|| .|.|         :..:.|
 Frog   323 CVIVLNVSLRSPSTHTLSSKVKHMLLEVLPQFIHLRVEPCDEGEE-TPRERRRSSLGIMLKAEEY 386

  Fly   377 HL-PPDVDKFVNYDSKRFSGDYGIPALPASHR---FDLAAAGGISAHCFAEPPLPSSLPLPGADD 437
            .| .|..:.......:|    :|:...|..:|   ||:    |::...:..
 Frog   387 VLKKPRSELMFERQRER----HGMRREPDGYRADGFDV----GVTTTLYRN-------------- 429

  Fly   438 DLFSPSGLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEE 502
                        ...|.|                    |::..::...||.|:.|:.:...:..|
 Frog   430 ------------LAQCAP--------------------EIKDCVDACNFITQNTKDDNATGAEME 462

  Fly   503 DWKYVAMVLDRMFLWIFAIACVVGTALIIL 532
            :|..:..|||.:..|:.....|:||..|.|
 Frog   463 NWVLIGKVLDVLCFWVALPLFVLGTLAIFL 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	93/223 (42%)
		LIC	27..530	CDD:455710	180/522 (34%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrne	XP_002941867.4	LGIC_ECD_nAChR_G	47..241	CDD:349830	85/197 (43%)
		Cys-loop	148..162	CDD:349830	8/13 (62%)
		Neur_chan_memb	248..491	CDD:460753	83/297 (28%)