Protein Alignment nAChRalpha1 and chrna2

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_004914998.2
• Gene: chrna2 / 100495873
• XenbaseID: XB-GENE-1013893
• Length: 510
• Species: Xenopus tropicalis
• Alignment Length: 529
• Identity: 250/529 - (47%)
• Similarity: 323/529 - (61%)
• Gaps: 81/529 - (15%)

  Fly    26 KRLYDDLLSNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNP 90
            :||:..|.:.|||..|||.|.||.:.||.||.::|||||:.|||:||||||::||||||||:|||
 Frog    33 ERLFKRLFTGYNRWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNP 97

  Fly    91 DDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEY 155
            .||..|.::.||||.||:|||||||||||.:.:|.||||.|.|.|||.|.|||||||.|.|||.:
 Frog    98 ADYDNVTSIRVPSEMIWIPDIVLYNNADGEFAITHMTKAHLFHNGKVKWVPPAIYKSSCSIDVTF 162

  Fly   156 FPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKFY 220
            ||||:|:|.|||||||||...:||         :::|..:||:||:.|.||.|:......|.|.|
 Frog   163 FPFDQQSCKMKFGSWTYDKAWLDL---------ESMERNVDLKDYWESGEWAIVNAVGKYNSKKY 218

  Fly   221 SCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCISILLSLTVF 285
            .||.|.|.||.:...:||..||||:||||||:.||.|:|||||||||.||||:||||:|||||||
 Frog   219 DCCTEIYPDITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVF 283

  Fly   286 FLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVTHRMAPWVQRLFIQILP 350
            .||:.||||.|||.:||:|:||||||:.||||:|:|:.||||:.|||.||:|..||:.:|:..:|
 Frog   284 LLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHKMPLWVRSVFLDHIP 348

  Fly   351 KLLCIERPK---KEEPEEDQPPE--VLTDVYHLPPDVD-----------------KFVNYDSKRF 393
            :.|.::||.   :|...:...||  :.|..|.:..|||                 ...:..|.::
 Frog   349 RWLFMKRPPAPVEEVVSQYDAPELKLSTSKYWMETDVDDKWAEPEAELQTCHVRHMTTHNQSLQY 413

  Fly   394 SGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPAAA 458
            ..||       :|.    .:||.|     :.|..||.. ......|.|||.|
 Frog   414 RYDY-------NHH----VSGGQS-----QTPRHSSTE-TAESSFLLSPSVL------------- 448

  Fly   459 AAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVAMVLDRMFLWIFAIAC 523
                                |.:||..:||.|::.:|...||:|||||||||:||:|||:|.|.|
 Frog   449 --------------------KALEGVHYIANHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVC 493

  Fly   524 VVGTALIIL 532
            ::||..:.|
 Frog   494 LLGTVGLFL 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	120/215 (56%)
		LIC	27..530	CDD:455710	249/524 (48%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
chrna2	XP_004914998.2	LIC	9..503	CDD:455710	250/529 (47%)
		LGIC_ECD_nAChR_A2	32..238	CDD:349816	120/213 (56%)
		Cys-loop	156..170	CDD:349816	9/13 (69%)