Protein Alignment nAChRalpha1 and chrna5

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: XP_002937929.1
• Gene: chrna5 / 100379824
• XenbaseID: XB-GENE-5755296
• Length: 476
• Species: Xenopus tropicalis
• Alignment Length: 544
• Identity: 206/544 - (37%)
• Similarity: 301/544 - (55%)
• Gaps: 137/544 - (25%)

  Fly     9 VFIALHFATG--GLANPD--AK---RLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDV 64
            :|:.|....|  |::.|.  ||   ||:..|.  .:|.|.:|||.:.:|.:.||.||.::||:||
 Frog    26 LFLCLDILHGACGISEPSYIAKSEDRLFKYLFQQQDYQRWVRPVEHLNDTVKVKFGLAITQLVDV 90

  Fly    65 NLKNQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKA 129
            :.|||:||||||::|||.|.||:|:|:::.|:.::.|||:.||:||||||:||||.:|.:: |||
 Frog    91 DEKNQLMTTNVWLKQEWVDVKLRWDPNEFAGITSIRVPSDSIWIPDIVLYDNADGRFEGSV-TKA 154

  Fly   130 ILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDL----RHLKQTADSDN 190
            ::.:.|.:.|.|||.|||.|.|||.:||||.|.|.||||||||||..||:    .|
 Frog   155 VVRYDGTINWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDYH--------- 210

  Fly   191 IEVGIDLQDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGIS 255
                :|.:|::.:.||:|:.....:..:...||..||  |.::..::|..||||:.|||||:|:|
 Frog   211 ----VDKRDFFDNGEWEIVNATGNKGNRTDGCCFYPY--ITYSFIIKRLPLFYTLFLIIPCIGLS 269

  Fly   256 FLSVLVFYLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVV 320
            ||::|||||||:.|||||||.|:|:|||||.|::.||||.:|..:||:|:||:|||:.||||:|:
 Frog   270 FLTILVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIVL 334

  Fly   321 TIAVLNVNFRSPVTHR-MAPWVQRLFIQILPKLLC----IER--PKKEEPEEDQPPEVLTDVYHL 378
            |:..:|::.||..||. |||||:::|:..||||||    ::|  .:|:|..:.:.||
 Frog   335 TVFAINIHNRSSATHNAMAPWVRKIFLHKLPKLLCMRSHVDRYFTRKDETGKVRGPE-------- 391

  Fly   379 PPDVDKFVNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPS 443
                                      |.|..|.||
 Frog   392 --------------------------SSRNTLEAA------------------------------ 400

  Fly   444 GLNGDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVA 508
                                                 ::..|:|.:||..:.:.:.|.||||:||
 Frog   401 -------------------------------------LDSIRYITRHVMKEHEVQEVVEDWKFVA 428

  Fly   509 MVLDRMFLWIFAIACVVGTALIIL 532
            .||||||||.|.:..|:|:..:.:
 Frog   429 QVLDRMFLWTFLLVSVIGSLFLFI 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	98/228 (43%)
		LIC	27..530	CDD:455710	199/515 (39%)
		Cys-loop	149..163	CDD:349832	9/13 (69%)
chrna5	XP_002937929.1	LIC	19..453	CDD:455710	206/544 (38%)
		LGIC_ECD_nAChR_A5	47..255	CDD:349819	97/223 (43%)
		Cys-loop	174..188	CDD:349819	9/13 (69%)