Protein Alignment nAChRalpha1 and si:ch211-256e16.4

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001429417.1
• Gene: si:ch211-256e16.4 / 100333796
• ZFINID: ZDB-GENE-131121-267
• Length: 412
• Species: Danio rerio
• Alignment Length: 312
• Identity: 76/312 - (24%)
• Similarity: 149/312 - (47%)
• Gaps: 26/312 - (8%)

  Fly    34 SNYNRLIR--PVGNNSDRLT-------------VKMGLRLSQLIDVNLKNQIMTTNVWVEQEWND 83
            ::|.:|.:  .:|.|.:|.|             |.:.|.::.:::|..|.|.::|.|.:...|.|
Zfish    36 NSYEQLYKYLGLGGNDNRTTYMRPMFPGQTYTRVLVDLYVTSIVEVFEKEQRLSTQVKMITVWFD 100

  Fly    84 YKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILHHTGKVVWKPPAIYKSF 148
            ..:.||...:..:.|:..|....|.||||:..:..........:...|...|.||........:.
Zfish   101 SNVLWNSYKFCQILTIAAPRNLFWRPDIVIAESVKTEIGTVESSYVQLVFFGYVVLPEVLSLNTV 165

  Fly   149 CEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDLQDYYISVEWDIMRVPA 213
            |::::..||||.|:|.:...|..|..  |||:  .:|.....:......|.:....||:::.:..
Zfish   166 CKLNLYRFPFDTQSCNITIQSVAYSN--VDLK--LETLHDTGVLTNSSKQSFQSQGEWELLNIST 226

  Fly   214 VRNEKFYSCCEEPYLD-IVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPSDSGEKISLCIS 277
            .:::.|...   .|.| :::.:|::|:.|.:.:|:|:|......|.|..:::.:|..:|:|..::
Zfish   227 SKSKVFLMF---GYADQLIYQITIKRRPLLHVINIILPVFFFLVLDVTSYFIDTDGADKLSFKVT 288

  Fly   278 ILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNF 329
            :||:::|..|:|.:.:|.|:..:||:|.|......|:.:|::.||.   |||
Zfish   289 LLLAISVLLLILNDTLPSTTYELPLIGIYCSAIFSLIGISILETIL---VNF 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	49/223 (22%)
		LIC	27..530	CDD:455710	76/312 (24%)
		Cys-loop	149..163	CDD:349832	6/13 (46%)
si:ch211-256e16.4	NP_001429417.1	None