Protein Alignment nAChRalpha1 and chrnb2

DIOPT Version :10

• Sequence 1: NP_001262916.1
• Gene: nAChRalpha1 / 42918
• FlyBaseID: FBgn0000036
• Length: 597
• Species: Drosophila melanogaster
• Sequence 2: NP_001093684.1
• Gene: chrnb2 / 100101688
• XenbaseID: XB-GENE-854457
• Length: 499
• Species: Xenopus tropicalis
• Alignment Length: 545
• Identity: 231/545 - (42%)
• Similarity: 327/545 - (60%)
• Gaps: 89/545 - (16%)

  Fly     5 LFAAVFIALHFATGGLANPDAKRLYDDLL--SNYNRLIRPVGNNSDRLTVKMGLRLSQLIDVNLK 67
            |.||:::.|....|.|.....:||.:.||  |.||:||||..|.|:::||::.:.|:|||.|:.:
 Frog     9 LLAALYLLLGLLPGCLGTDTEERLVEHLLDPSRYNKLIRPATNGSEQVTVQLMVSLAQLISVHER 73

  Fly    68 NQIMTTNVWVEQEWNDYKLKWNPDDYGGVDTLHVPSEHIWLPDIVLYNNADGNYEVTIMTKAILH 132
            .||||||||:.|||.||:|.|:|.::..:..:.:||:||||||:||||||||.|||:..:.|::.
 Frog    74 EQIMTTNVWLTQEWEDYRLTWDPAEFDDMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVS 138

  Fly   133 HTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRHLKQTADSDNIEVGIDL 197
            |.|.:.|.|||||||.|:|:|::||||:|.|.|||.|||||...:||......|         .|
 Frog   139 HDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTELDLVLRSDVA---------SL 194

  Fly   198 QDYYISVEWDIMRVPAVRNEKFYSCCEEPYLDIVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVF 262
            .|:..|.||||:.:|..|||   :..:..|:||.::..:|||.||||:||||||:.|:.|::|||
 Frog   195 DDFTPSGEWDIIALPGRRNE---NPNDSTYVDITYDFIIRRKPLFYTINLIIPCILITSLAILVF 256

  Fly   263 YLPSDSGEKISLCISILLSLTVFFLLLAEIIPPTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNV 327
            |||||.|||::||||:||:||||.||:::|:|||||.|||:||||:|||:|||.|:|.::.||||
 Frog   257 YLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNV 321

  Fly   328 NFRSPVTHRMAPWVQRLFIQILPKLLCIERPKK-------EEPEEDQPPEVLTDVYHLPPDVDKF 385
            :.|||.||.|.|||:.:|:..||.||.:::|::       .:..:.|
 Frog   322 HHRSPTTHTMPPWVKVVFLDKLPTLLFMKQPRQNCARQRLRQQRQSQ------------------ 368

  Fly   386 VNYDSKRFSGDYGIPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGAD-DDLFSPSGLN--- 446
                 :|.:|.:            ....|..|..|:..   .:|:...||. .:|  |.|:|
 Frog   369 -----ERAAGSF------------FLRDGARSCTCYVN---QASVKKYGAQLSEL--PEGVNGFR 411

  Fly   447 ---GDISPGCCPAAAAAAAADLSPTFEKPYAREMEKTIEGSRFIAQHVKNKDKFESVEEDWKYVA 508
               |.:....|                     .:::.::|.||||.|:|::|..:||.|||||||
 Frog   412 DRQGKVRQCLC---------------------GLQEAVDGVRFIADHMKSEDDDQSVSEDWKYVA 455

  Fly   509 MVLDRMFLWIFAIACVVGTALIILQ 533
            ||:||:|||||...||.||..:.||
 Frog   456 MVIDRLFLWIFVFVCVFGTIGMFLQ 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha1	NP_001262916.1	LGIC_ECD_nAChR_proto_alpha-like	24..242	CDD:349832	103/219 (47%)
		LIC	27..530	CDD:455710	223/518 (43%)
		Cys-loop	149..163	CDD:349832	8/13 (62%)
chrnb2	NP_001093684.1	LIC	29..479	CDD:455710	223/522 (43%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	102/214 (48%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)