Protein Alignment CG6454 and c2cd5

DIOPT Version :10

• Sequence 1: NP_651249.2
• Gene: CG6454 / 42904
• FlyBaseID: FBgn0039187
• Length: 1569
• Species: Drosophila melanogaster
• Sequence 2: XP_021323279.1
• Gene: c2cd5 / 393585
• ZFINID: ZDB-GENE-041114-193
• Length: 1218
• Species: Danio rerio
• Alignment Length: 1621
• Identity: 529/1621 - (32%)
• Similarity: 760/1621 - (46%)
• Gaps: 491/1621 - (30%)

  Fly     1 MPGKVGVKIKAARNLPVMDKSSETTDAFVEIKLASVTHKTDVFRKSLNPTWNTDWFRFEVDDAEL 65
            ||||:..||.|.|:|||||::|:.||||||:|..:.|:||||:.|||||.||::||:|||||.:|
Zfish     1 MPGKLKAKIVAGRHLPVMDRASDLTDAFVEVKFGNTTYKTDVYPKSLNPQWNSEWFKFEVDDEDL 65

  Fly    66 QDEPLQIRLMDYDTYSANDAIGKVNISLNP-LCLESSSQAVHGKGTVLSGWIPVFDTMHGIRGEI 129
            |||||||.::|:||||||||||||.|.::| ||.|::        ||:|||:|::||:|||||||
Zfish    66 QDEPLQITVLDHDTYSANDAIGKVYIDIDPLLCSEAA--------TVISGWLPIYDTIHGIRGEI 122

  Fly   130 NVIVKVDLFSDVNKFRQSSCGIPFFHSQCVPFGYRAQVIHGFVEELVVNDDPEYQWIDKIRTPRA 194
            ||:||||||:|:|:|||||||:.||.:..:|..|||.::||||||||||:||||||||:||||||
Zfish   123 NVLVKVDLFNDLNRFRQSSCGVKFFCTTSIPRCYRAIMVHGFVEELVVNEDPEYQWIDRIRTPRA 187

  Fly   195 SNEARQVVFLKLSGQVQRRMGLKAINMGANAVIGYTQCFDLEGDVGVVARGIGTAVTLIK----- 254
            ||||||.:...:||::||::|||.:.||.|||:||.|||||||:.|:|.|.||||.||.|
Zfish   188 SNEARQRLIFLMSGELQRKIGLKVLEMGGNAVVGYLQCFDLEGESGLVVRAIGTACTLEKISTLP 252

  Fly   255 DTSTSQPNSADVALIEELTQKYLDFLNCAGASNSSLPLSGRTPQYRLNIYREPSSSAPSSAAAAA 319
            .|:|.|.||:....:::..|.....|.|....:|.:               ..:||..|...:.:
Zfish   253 STATHQSNSSPSKDMKDSPQAAPSTLGCRSTHSSPV---------------HSASSRLSQGFSVS 302

  Fly   320 AATMFYLESASSDTEDAELMQNLIRQEDERGDRNREKKLRHRMRRLTLSSSKIFSQKYATLIRRI 384
            ..|:.:                            ...|.|||       ||:      |...|:.
Zfish   303 VPTLLF----------------------------AGMKPRHR-------SSE------APRARQC 326

  Fly   385 EPKIPENATQSLSSIFGGATAATSSFRRRRKSRFAASTSKSSIPPFITRSISSDSNVRPGRMPIK 449
            .|            :||
Zfish   327 RP------------VFG------------------------------------------------ 331

  Fly   450 SFLTVPGLMEYQENTRSAPDLPGDEFQARTRPTSNYSTESEDSLQLDLEIGPPESNAEDSPEEEE 514
                              .::||                      :.|..|||      :|
Zfish   332 ------------------EEVPG----------------------IPLSSGPP------TP---- 346

  Fly   515 DLQDNWIKPGETRSCENSQQDLGPSHHNLLDDLKGFSRRLQKMMHLSPKSSDIEKKLPFVPSLER 579
                                                 .|.|.....||..|
Zfish   347 -------------------------------------LRAQTFSSFSPSKS-------------- 360

  Fly   580 KPYYSSQPELPSCSNDCLVSNLSGSSSMLQLNFLPSYGKTMQRSASLNHLVAPDTPVPPNTLLLK 644
               ||.|                .|||..:|:..|                             |
Zfish   361 ---YSRQ----------------SSSSDTELSLTP-----------------------------K 377

  Fly   645 APELRVCPSTPTPTQSNLVVFDYNNSPCLTQLDQSVNISNSTNHSNHNNESSLLAPFAIRQQQPP 709
            ...:.:|||||..                    :|::.|..:.|
Zfish   378 TVRMFLCPSTPAL--------------------ESISSSLPSTH--------------------- 401

  Fly   710 RVIRSSSELQQQPC----STGAAASTGPSNIPTTVEGSSPNLKRFASPVSSSRLKLTPSPSKSGI 770
                       .||    ...:.:||.|   |..|..|...:.| .|...|..|.|..|...||.
Zfish   402 -----------MPCHLRPGMASRSSTPP---PLHVSQSDTAMLR-KSVSFSEELLLAASGMGSGG 451

  Fly   771 SATTNADSASTSTASTATTMVPATVGEICRRSSDSDLSVTPKGNSICVASERLVAATAMMRLTQP 835
            ||...|                ..:..:.|:.:.|.|    :...:..:||..|
Zfish   452 SAGKEA----------------GPLKALLRQQTQSAL----EQRGVSSSSEAFV----------- 485

  Fly   836 TVGAKPGTAADSLDMLEYPFLTMTKYPTGFILHLGATVAARSVKLLERVPNP------------- 887
                :.|         ||||.|:|.:|:||:||:|..|:|||||||:|:.||
Zfish   486 ----RTG---------EYPFFTLTSFPSGFLLHVGGVVSARSVKLLDRIHNPALGNTRSYKLLDW 537

  Fly   888 -----DEPEVRDSWWTELRMEIRSHARSLGCNVVLGYAETTTISDDVCVLSATGTAAVINMVFNR 947
                 ||||.||:||.|:|.||:|||::|||:.|:||:|:|:|.::||:|||:||||:::..|.:
Zfish   538 NSFTADEPETRDAWWEEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAILSSRFMQ 602

  Fly   948 SVSQTDIFTMSKATASVAAMTNSVEDGNGSTAGDTSIGKDSGSLGTGNSSGGKRYGLPPLNGPRN 1012
            .........:|:.....:..:..||...||:|   |:|.:.              .:||
Zfish   603 DGPLDTEHRLSRQPLVFSTGSERVEGDMGSSA---SLGFEE--------------VVPP------ 644

  Fly  1013 ACAICHIPYNLSSVPFNVKMKKCAVCRKGRVPDVLLATLEVPEFMQVTGRGCFMQAQVVRAKRDL 1077
            .|..|||||:..::||..::..|..||:.:|||||..|:::|....:||:||.:||::.|.|:..
Zfish   645 GCGFCHIPYDELNIPFPAQLTYCYSCRRSKVPDVLFTTIDLPADANITGKGCLIQARLCRTKKKA 709

  Fly  1078 RAELNAKEISDGLPFLEYELHRVLINKLKAKGMNAIFGLRTQVAIGERMIALIATGTALFLTALP 1142
            :.|.||..||:.|||||||||..|:||||.:||||:||||.|:::||.|:..:|:.|.::|||||
Zfish   710 QGEGNATAISNLLPFLEYELHTQLMNKLKLRGMNALFGLRIQISVGETMLLGLASATGVYLTALP 774

  Fly  1143 VPQVPKIVAGNSWTD---KQKLNELQKKLQETFERNQEIYQLKSLDPDLAANVGGVP---STGAS 1201
            .|...:| ||.:.:|   :|.::.:|||:.:|..:|:::|::.  .|::...:.|.|   ....|
Zfish   775 GPGGIQI-AGKTPSDITYEQHISNMQKKINDTIAKNKDLYEIN--PPEVVEEIIGSPIPEPRQRS 836

  Fly  1202 GDKQSDTDDSDEEEMNEIDLNCGNKELCVLEVDDIEDLEIISLLMEPYP-PEGFHVVNTQQVPGM 1265
            ...:|.::.||  |::|:||:.|.|:..|||:||.:.:|.|..|:...| |:||:..||:.:||:
Zfish   837 RLFRSQSESSD--EVSELDLSHGKKDAFVLEIDDTDAVEDIHALLTDSPTPQGFYSCNTEIMPGI 899

  Fly  1266 LEMDTVKNLQMFTQVWRARLEVGQSVN-GFPKHF----QRLLQTIYFKLRTMIPCAICDLRFRLD 1325
              .:....:||||.|...||......| |..|.|    :.||:::|||||:|:||.:|.|.|.:.
Zfish   900 --QNWTSAIQMFTSVRVFRLNNANLTNQGLNKIFSDLCENLLKSLYFKLRSMVPCCLCHLNFTVA 962

  Fly  1326 LPETDQIQLLVTGMAMGLSDANRMKYRGRGRPAQQQQAPQQQNGYHDGTVHATQSQPELNGKRML 1390
            :||.:.||:.||.:||.......:                 :||...|....|::..|
Zfish   963 IPEDELIQVAVTAVAMSFDKEQIL-----------------ENGKQSGEKTLTKAITE------- 1003

  Fly  1391 QEEDYIFPLDEDQMVDTPTPTSTAIPPFGMSSFKMRKTSPSRLNNLVSGLPSTGVKPLNVGSVQ- 1454
            .:|...|.|:.:.......|.|:   |.|:|......::..|.::.:..| ......:..|||:
Zfish  1004 NDEQLQFNLELNPESSHANPLSS---PKGLSEVGSHPSARDRCSSWIEQL-RLKAHTIRRGSVKT 1064

  Fly  1455 -------------RSRYFPLRDRYG------VDVTPLSFIPGGRIDKYLGNLNFFFIRESTSIRE 1500
                         |||.......|.      |.:||||||||.:|.||||.:|.|||||:||:||
Zfish  1065 TSSMEKASPLPEGRSRSLRSNRSYSGTSVAVVKMTPLSFIPGAKIIKYLGIINMFFIRETTSLRE 1129

  Fly  1501 NGGISGFVHGFITELLAVVRAHIASLGGNAMVSFYITELMLFDNQHKNQGQCLISIGGDAV 1561
            .||:|||:|.||.|:.|:||||:|:|||||:||:.:.|.:..:|.:|||.||||::.||||
Zfish  1130 EGGVSGFLHSFIAEVFAMVRAHVAALGGNAVVSYSMKECVFMENPNKNQAQCLINVSGDAV 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6454	NP_651249.2	C2_KIAA0528-like	5..121	CDD:176070	68/116 (59%)
c2cd5	XP_021323279.1	C2_KIAA0528-like	5..114	CDD:176070	68/116 (59%)