Protein Alignment twin and NGL2

DIOPT Version :10

• Sequence 1: NP_732964.1
• Gene: twin / 42880
• FlyBaseID: FBgn0011725
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_014012.1
• Gene: NGL2 / 855329
• SGDID: S000004898
• Length: 515
• Species: Saccharomyces cerevisiae
• Alignment Length: 489
• Identity: 112/489 - (22%)
• Similarity: 177/489 - (36%)
• Gaps: 180/489 - (36%)

  Fly   184 VNP--PPQ-----RPWLPLAKPNKTRPAC--IFTVMCYNVLCDKYATRQMYGYCPSW--ALCWEY 237
            |:|  ||:     ||:|.|   ::..|..  .|.:|.||.|......|:::   |..  ||.|..
Yeast    83 VDPDCPPELHFIRRPFLSL---HEAEPVTGFRFKLMTYNCLAQALIRRKLF---PDSGDALKWYR 141

  Fly   238 RKKSIIDEIRHYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCA 302
            |.|.:::|.::|.:|:|.||||:..||..|:..|....||:|.:   .|..|.:.       |.|
Yeast   142 RSKVLLNEFKYYNSDVICLQEIDHIQFQSFWKDEFSKLGYDGQY---YRNATKNH-------GVA 196

  Fly   303 IFFRASKFTLIKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPMSEVTQIS 367
            |.:|...|..:.:.||::::      |.|:::..|. ..:|:||...||..|.....:.:.:...
Yeast   197 IMWRRELFHQVDKMLIDYDK------ESSESISTRT-TTNNVGLVLALKFSEKVLSNLGKKSSKK 254

  Fly   368 QPLLVCTAHIHWDP-------EFCDV---KLIQTMMLSNELKTIID-EASHSFRPGHKNDSNAVQ 421
            ..:|:.|.|:.|.|       ..|.:   |:.:.|...|.|:...| :.||.|.
Yeast   255 CGILIGTTHLFWHPFGTYERTRQCYIVLKKMKEFMHRVNVLQNENDGDLSHWFP----------- 308

  Fly   422 LLLCGDFNSLP--------------------------------------------DSGVVEFLGK 442
             ..||||||.|                                            :.|.:|..||
Yeast   309 -FFCGDFNSQPFDTPYLSMTSKPVHYRNRAKTVIGCSTSYKFSKVRDGEEGADDEEGGNIEKYGK 372

  Fly   443 GR----------------------------VSMDHLDFKDMGYKSCLQRL--LSNDTNEFTHSFK 477
            .:                            :.|..:....:|||:.....  |.||..|
Yeast   373 DQPESPVPEKFHANEEQSELVDKMAQLHNSLDMRAISLYSVGYKNVHPENAGLDNDRGE------ 431

  Fly   478 LASAYNEDIMPH-TNYTFDFKGIIDYIFYTKTGMVPLGLLGPVSN--------DWLRENKV---- 529
                      |. :|:...::|::||:||.|.       ..|.||        |:.:||||
Yeast   432 ----------PEISNWANTWRGLLDYLFYVKK-------WDPQSNCQEVETLGDFEKENKVKCRG 479

  Fly   530 -VGCP---------HPHI---PSDHFPLLVELEL 550
             :..|         .||:   .|||..::.:|||
Yeast   480 FLRMPPGNEMTKHGQPHVGEYASDHLSMVCDLEL 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR	<52..>155	CDD:443914
		leucine-rich repeat	76..98	CDD:275378
		leucine-rich repeat	99..121	CDD:275378
		leucine-rich repeat	122..144	CDD:275378
		leucine-rich repeat	145..156	CDD:275378
		Deadenylase_CCR4	209..550	CDD:197331	100/453 (22%)
NGL2	NP_014012.1	CCR4	82..515	CDD:227564	112/489 (23%)