Protein Alignment twin and Angel1

DIOPT Version :10

• Sequence 1: NP_732964.1
• Gene: twin / 42880
• FlyBaseID: FBgn0011725
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: XP_011242471.1
• Gene: Angel1 / 68737
• MGIID: 1915987
• Length: 690
• Species: Mus musculus
• Alignment Length: 686
• Identity: 140/686 - (20%)
• Similarity: 235/686 - (34%)
• Gaps: 207/686 - (30%)

  Fly    16 MKGNHYKMSRNKDKYDSANRRQQIFLSQEDIAAGKKTNWSGLEITGCVRNISPSLWEFEHLTALY 80
            ::||.....|..|:.:.....||          .::..|:....|.....::........|..|.
Mouse    64 VEGNFAMAPRGPDQEECEGLLQQ----------WREEGWNQTPSTASEGPLADKGLAESSLALLM 118

  Fly    81 LNDNQLLRLPADVGMLTSLRTLDLSSNKLRSLPAELGELIQLRELL--LNNNFLRVLPYEIGKLF 143
            .|..:......|......|..|..:.|..:..|..|||     |.|  :.......:|.:.|..:
Mouse   119 DNSGEQDAASEDKWSSRQLSDLRAAENLNQPFPEVLGE-----EPLAEVEGPLWAAVPVQTGPQY 178

  Fly   144 ---HLVILGLMGNPLQKE-----FMNIYNEPNGTQKLLTYMLDNLSFTVNPPPQ---------RP 191
               .::.:|.|.....:|     ..:|..||...::...:..:.|. .:.|||.         |.
Mouse   179 ADCAVLPMGAMAAEQWEEDPAMVAWSIAPEPMPQEETSMWPFEGLE-QLQPPPMEIPYHEILWRE 242

  Fly   192 WLPLAKPNKTR-------PACIFTVMCYNVLCD--KYATRQMYGYCPSWALCWEYRKKSIIDEIR 247
            |...:.....:       |...||:|.||:|..  ...:.::|.:|....|.|.||..:::.|.:
Mouse   243 WEDFSTQPDAQGLEAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFANLMQEFQ 307

  Fly   248 HYAADIISLQEIETEQFYHFFLPELKNDGYEGIFSPKSRAKTMSELERKYVDGCAIFFRASKFTL 312
            |:..||:.|||::.:.::....|.|:..|:...:..::..||         ||||:.::.::|.|
Mouse   308 HWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKT---------DGCAVCYKPTRFRL 363

  Fly   313 IKESLIEFNQLAMANAEGSDNMLNRVMPKDNIGLAALLKVKENAWEPM--SEVTQIS-QPLLVCT 374
            :..|.:|:.:..:       .:|||    ||:||..||       :|:  ..:.|:| .||.|..
Mouse   364 LCASPVEYFRPGL-------ELLNR----DNVGLVLLL-------QPLVPEGLGQVSVAPLCVAN 410

  Fly   375 AHIHWDPEFCDVKLIQTMMLSNELKTI--IDEASHSFRPGHKNDSNAVQLLLCGDFNSLPDSGVV 437
            .|:.::|...||||.|..:|..|:..:  :.:.||            ..::||||.||:|||.:.
Mouse   411 THVLYNPRRGDVKLAQMAILLAEVDKVARLSDGSH------------CPIILCGDLNSVPDSPLY 463

  Fly   438 EFLGKGRVSMDHL---------DF---------------KDMGYKSCLQRLLS------------ 466
            .|:..|.:..:.:         ||               ..:|...|.|.:.|
Mouse   464 NFIRDGELQYNGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDCCQYVTSCHPKRSERLKYG 528

  Fly   467 --------------------------NDT----------------------------NEFTHSFK 477
                                      .||                            ....|...
Mouse   529 RDFLLRFRFCDLACQRPVGLVLMEGVTDTKPDRPAGWAECIFEEEISELEPVFPRTIGTIQHCLH 593

  Fly   478 LASAYNEDIMPH-----TNYTFDFKGIIDYIFYT---------------KTGMVPLGLLGPVSND 522
            |.|.|...:..|     |.........:||||::               :.|  .|.|||.:|
Mouse   594 LTSVYTHFLPQHGCPEVTTMPLGLGMTVDYIFFSAESCENENRTDHRLDRDG--TLKLLGRLS-- 654

  Fly   523 WLRENKVV----GCPHPHIPSDHFPLLVELELMHTA 554
             |...:::    |.|:|...|||..||....:..||
Mouse   655 -LLSEEILWAANGLPNPFYSSDHLCLLASFGMEVTA 689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twin	NP_732964.1	LRR	<52..>155	CDD:443914	19/107 (18%)
		leucine-rich repeat	76..98	CDD:275378	4/21 (19%)
		leucine-rich repeat	99..121	CDD:275378	7/21 (33%)
		leucine-rich repeat	122..144	CDD:275378	4/26 (15%)
		leucine-rich repeat	145..156	CDD:275378	2/10 (20%)
		Deadenylase_CCR4	209..550	CDD:197331	100/461 (22%)
Angel1	XP_011242471.1	EEP	268..683	CDD:469791	100/458 (22%)