DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6178 and CG18586

DIOPT Version :9

Sequence 1:	NP_651221.1	Gene:	CG6178 / 42867	FlyBaseID:	FBgn0039156	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	143/532 - (26%)
Similarity:	246/532 - (46%)	Gaps:	47/532 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SLGQYILDKYKSFGDRT------VLVDAVNGVEYSASFMHKSIVRLAYILQKLGVKQNDVVGLSS 84
            |:|:.|      |||..      ..:.....:..:...:|.:.:|:|..::.:|:.|.|:||:..
  Fly    38 SIGEII------FGDMVNNPKLIAQISITEDIVLTREDLHMNAMRVASYMRNMGLGQTDIVGVMG 96

  Fly    85 ENSVNFALAMFAGLAVGATVAPLNVTYSDREVDHAINLSKPKIIFASKITIDRVAKVASKNKFVK 149
            .::.:.:...:|....|..:..|:..|.:..:.....::||::||...   |...||.|..|.::
  Fly    97 RHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRLIFCDG---DEYEKVKSATKDLQ 158

  Fly   150 -GIIALSGTSKKFKNIYDLKELMEDEKFKTQPDFTSPAANKD--EDVSLIVCSSGTTGLPKGVQL 211
             .|:.:....:....|.|:......:.|:       |...||  :....|:.||||:|.||.|.:
  Fly   159 VTIVTMRNHPRGSVRIQDVLTTPVMQNFQ-------PLRLKDGIDHTLAILSSSGTSGFPKAVTI 216

  Fly   212 TQ-----MNLLATLDSQIQPTVIPMEEVTLLTVIPWFHAFGCLTLITTACVGARLVYLPKFEEKL 271
            :.     ::.:|..:|.||.|...::..:.|::......|...::|...          .|:..|
  Fly   217 SNSHKIIVDYMAINNSNIQYTSSTLDWCSGLSMAITSGVFSTTSIIADC----------DFDPGL 271

  Fly   272 FLSAIEKYRVMMAFMVPPLMVFLAKHPIVDKYDLSSLMVLLCGAAPLSRETEDQIKERIGVPFIR 336
            |..||.|||:.|..:....:...|..|..:..|||||..::.|.:..|.|.:.:::.|:....:.
  Fly   272 FCRAIGKYRISMVLLSSSYLAIFANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRSRLSHDCLN 336

  Fly   337 QGYGLSE--STLSVLVQNDEFCKPGSVGVLKVGIYAKVIDPDTGKLLGANERGELCFKGDGIMKG 399
            ..|||:|  |..||.:..||  ||.|||....||..|||| :.|:....|..||:||.......|
  Fly   337 FCYGLTELNSAGSVNLNFDE--KPNSVGRAIRGIKIKVID-EQGEAQEPNVVGEICFHNSQKWAG 398

  Fly   400 YIGDTKST-QTAIKDGWLHTGDIGYYDDDFEFFIVDRIKELIKYKGYQVPPAEIEALLLTNDKIK 463
            |..:...| |....:.|:||||:||.|.|...|::||:|:::||:.....|:|||.::.....:.
  Fly   399 YYKNPDETRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVL 463

  Fly   464 DAAVIGKPDEEAGELPLAFVVKQANVQLTENEVIQFVNDN-ASPAKRLRGGVIFVDEIPKNPSGK 527
            :|.|.|..|...|:...|.:||:...||...:|:::|... .:..|:|.||.:.||:|.::.:.|
  Fly   464 EACVFGIWDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVDQIVRSGNRK 528

  Fly   528 ILRRILREMLKK 539
            ..|..::|...|
  Fly   529 TNRSAVKEHFLK 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6178	NP_651221.1	PLN02246	26..537	CDD:215137	142/528 (27%)
CG6178	NP_651221.1	Firefly_Luc_like	43..529	CDD:213279	134/497 (27%)
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	143/532 (27%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	134/497 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920