Protein Alignment Mettl3 and mettl3

DIOPT Version :10

• Sequence 1: NP_651204.1
• Gene: Mettl3 / 42844
• FlyBaseID: FBgn0039139
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: NP_001016419.1
• Gene: mettl3 / 549173
• XenbaseID: XB-GENE-922807
• Length: 573
• Species: Xenopus tropicalis
• Alignment Length: 656
• Identity: 308/656 - (46%)
• Similarity: 383/656 - (58%)
• Gaps: 157/656 - (23%)

  Fly     1 MADAW-DIKSLKTKRNTLREKLEKRKKERIEILS-DIQED-----------------LTNPKK-- 44
            |:|.| .|::.|.:.:.|||:|::|:|:....|. |:|..                 .|.|.|
 Frog     1 MSDTWSSIQAHKKQLDNLRERLQRRRKDATSQLGLDLQSSEGGIAPTFRSDSPVPSASTQPLKGP 65

  Fly    45 ---ELVEADLEVQKEVLQALSSCSLALPIVSTQVVEKIAGSSLEM----VNFILGKLANQGAIVI 102
               ..|..|.|::|::|..||..||.||..|..:...|......:    |..:|.|.|.|..|.:
 Frog    66 SGSAEVTPDPELEKKLLHHLSDLSLVLPADSVSIQLAITTPDFPVTRQGVESLLQKFAAQELIEV 130

  Fly   103 R--------NVTIGTEAGCEIISVQPKELKEILEDTNDTCQQKEEEAKRKLEVDD---------- 149
            :        ..|:.|.|....:|..   :..:.|....|.....:  ||:|:..|
 Frog   131 KGWGQEDDDRPTVVTFADHSKLSAM---MGAVTERKGSTIPAGAK--KRRLQEADPSASSLSSSS 190

  Fly   150 ---------VDQPQEKTIKLESTVARKESTSLDAPDDIMMLLSMPSTREKQSKQVGEEILELLTK 205
                     ..:||:|        |||.::.||.  :|..|||..||:|:|||:|.:||||||..
 Frog   191 SASASGEKKASEPQKK--------ARKNASHLDL--EIESLLSQQSTKEQQSKKVSQEILELLNT 245

  Fly   206 PTAKERSVAEKFKSHGGAQVMEFCSHGTKVECLKAQQATAEMAAKKKQERRDEKELRPDVDAGEN 270
            .||||:|:.|||:|.|.|||.|||.:|||.||:||.
 Frog   246 STAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKAA----------------------------- 281

  Fly   271 VTGKVPKTESAAEDGEIIAEVINNCEAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDESLG 335
                                              |:||       .|.||||::||..|||||||
 Frog   282 ----------------------------------GADT-------PCRKLHFRRIINMHTDESLG 305

  Fly   336 DCSFLNTCFHMATCKYVHYEVD---------TLPHINTNKPTDVKTKLSLKRSV-DSSC-TLYPP 389
            |||||||||||.||||||||:|         .:|....::.|      .|.::| |||. .|:|.
 Frog   306 DCSFLNTCFHMDTCKYVHYEIDAWVEPGGTAVVPEAVPSQDT------PLTKAVGDSSVGRLFPS 364

  Fly   390 QWIQCDLRFLDMTVLGKFAVVMADPPWDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWVTGRA 454
            |||:||:|:|||::||||:||||||||||||||||||::|||||.|.:|.|||||.:||||||||
 Frog   365 QWIRCDIRYLDMSILGKFSVVMADPPWDIHMELPYGTLTDDEMRKLQIPVLQDDGFLFLWVTGRA 429

  Fly   455 MELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGMKGNPTNLNRGLDCD 519
            |||||:||||||||||||:|||||||||||||||||||||||||||||||:||||...|||||||
 Frog   430 MELGRECLKLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNRGLDCD 494

  Fly   520 VIVAEVRATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQ 584
            |||||||:||||||||||:|||||||||||||||||||:||||||||||||||.|:||:::.:|:
 Frog   495 VIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFK 559

  Fly   585 KRYPDG 590
            ::||||
 Frog   560 QKYPDG 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl3	NP_651204.1	MT-A70	407..568	CDD:368270	142/160 (89%)
mettl3	NP_001016419.1	MT-A70	382..543	CDD:368270	142/160 (89%)