DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mettl3 and Mettl14

DIOPT Version :10

Sequence 1:NP_651204.1 Gene:Mettl3 / 42844 FlyBaseID:FBgn0039139 Length:608 Species:Drosophila melanogaster
Sequence 2:NP_001386178.1 Gene:Mettl14 / 295428 RGDID:1304822 Length:456 Species:Rattus norvegicus


Alignment Length:391 Identity:103/391 - (26%)
Similarity:152/391 - (38%) Gaps:103/391 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 LKAQQATAEMA------AKKKQERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIAEVINNC- 295
            |.|||..||.|      ...|.|:|:..|.|....|..:.:....| ....::||...:.:... 
  Rat    18 LLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNSK-RKCLDEGETDEDKVEEYK 81

  Fly   296 -EAESQESTDGSDTCSSETTDKCTKLHFKKIIQAHTDESLGDCSFLNTCFHMATCKYVHYEVDTL 359
             |.|.|:..:..........|..|.|...:.:..|.|                   |..:.||| 
  Rat    82 DELEMQQEEENLPYEEEIYKDSSTFLKGTQSLNPHND-------------------YCQHFVDT- 126

  Fly   360 PHINTNKPTDV------------------KTKLSLKRSVDSSCTLYPPQWIQCDLRFLDMTVL-G 405
            .|...|...||                  |.:|..|.:.       ||.::|.|:...|:..| .
  Rat   127 GHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNT-------PPMYLQADIEAFDIRELTP 184

  Fly   406 KFAVVMADPP------------------WDIHMELPYGTMSDDEMRALGVPALQDDGLIFLWV-T 451
            ||.|::.:||                  ||..|:|        |:..:..|.    ..||||. :
  Rat   185 KFDVILLEPPLEEYYRETGIAANEKCWTWDDIMKL--------EIDEIAAPR----SFIFLWCGS 237

  Fly   452 GRAMELGRDCLKLWGYERVDELIWVKTNQLQRIIRTGRTGHW-----LNHGKEHCLVGMKGNPTN 511
            |..::|||.||:.|||.|.:::.|:|||:    ...|:|...     ....|||||:|:||....
  Rat   238 GEGLDLGRVCLRKWGYRRCEDICWIKTNK----NNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKR 298

  Fly   512 ------LNRGLDCDVIVAEVRATSH--KPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQ 568
                  ::..:|.|:|:.|.....:  ||.||:.|||....|.|::.||||...|:|.|:|:|..
  Rat   299 STDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPT 363

  Fly   569 L 569
            |
  Rat   364 L 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mettl3NP_651204.1 MT-A70 407..568 CDD:368270 60/192 (31%)
Mettl14NP_001386178.1 MT-A70 186..363 CDD:368270 60/192 (31%)

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