Protein Alignment Mettl3 and Mettl14

DIOPT Version :10

• Sequence 1: NP_651204.1
• Gene: Mettl3 / 42844
• FlyBaseID: FBgn0039139
• Length: 608
• Species: Drosophila melanogaster
• Sequence 2: XP_317346.3
• Gene: Mettl14 / 1277842
• VectorBaseID: AGAMI1_004319
• Length: 392
• Species: Anopheles gambiae
• Alignment Length: 413
• Identity: 101/413 - (24%)
• Similarity: 163/413 - (39%)
• Gaps: 105/413 - (25%)

  Fly   235 VECLKAQQATAEMAAKKKQERRDEKELRPDVDAGENVTGKVPKTESAAEDGEIIAEVINNCEAES 299
            ||.||....|||.:..|.|...||:             ....||...||.  ::....:.....:
Mosquito    28 VEDLKHVLGTAEDSPIKSQRYEDEE-------------ASTSKTVQTAEG--LVYRDSSTFLKGT 77

  Fly   300 QESTDGSDTCSSETTDKCTKLHF-------KKIIQAHTDESLGDCSFLNTCFHMATCKYVHYEVD 357
            |.|...:|.|.          ||       :..|:   |..|.|             ::..|
Mosquito    78 QSSNPHNDYCQ----------HFVDTGQRPQNFIR---DVGLAD-------------RFEEY--- 113

  Fly   358 TLPHINTNKPTDVKTKLSLKRSVDSSCTLYPPQWIQCDLRFLDMTVLG-KFAVVMADPPWD---- 417
                      ..::..:.||..:.:. |..||.:::.||:..|:..|| ||.|::.:||.:
Mosquito   114 ----------PKLRELIRLKDELIAE-TATPPMYLRADLKTFDLKNLGTKFDVILIEPPLEEYAR 167

  Fly   418 ----IHMELPYGTMSDDEMRALGV-PALQDDGLIFLWV-TGRAMELGRDCLKLWGYERVDELIWV 476
                :....|....|.||:.||.: ........:|||. :...:::||:||:.||:.|.:::.|:
Mosquito   168 GGAAVAAGAPRNFWSWDEILALDIGEVAAHRSFVFLWCGSSEGLDMGRNCLRKWGFRRCEDICWI 232

  Fly   477 KTNQLQRIIRTGRTGH--------WLNHGKEHCLVGMKGNPTN------LNRGLDCDVIVAEVR- 526
            :||       ....||        .....|||||:|:||....      ::..:|.|:|::|..
Mosquito   233 RTN-------IDSPGHSKILEPKAVFQRTKEHCLMGIKGTVRRSTDGDFIHANVDIDLIISEEAE 290

  Fly   527 -ATSHKPDEIYGIIERLSPGTRKIELFGRPHNIQPNWITLGNQLDGIRLVDPELITQFQKRYPDG 590
             .:..||.||:.|||....|.|::.:|||...|:|.|:|:|.:|..... :.||.....:..|..
Mosquito   291 FGSLEKPIEIFHIIEHFCLGRRRLHIFGRDSTIRPGWVTIGPELTNSNF-NSELYASSFEENPTT 354

  Fly   591 NC------MSPAS--ANAASING 605
            .|      :.|.|  ||...:.|
Mosquito   355 GCTERIEALRPKSPPANGKVLRG 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mettl3	NP_651204.1	MT-A70	407..568	CDD:368270	54/186 (29%)
Mettl14	XP_317346.3	MT-A70	153..333	CDD:368270	54/186 (29%)