DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pli and Peli1

DIOPT Version :9

Sequence 1:	NP_001097890.1	Gene:	Pli / 42821	FlyBaseID:	FBgn0025574	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_075813.2	Gene:	Peli1 / 67245	MGIID:	1914495	Length:	418	Species:	Mus musculus

Alignment Length:	409	Identity:	247/409 - (60%)
Similarity:	309/409 - (75%)	Gaps:	9/409 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHS 87
            |..::||||::|||||.||.||||||:|:|.|.||.:|:|||.|..:|..:||.:|||.:.:|||
Mouse    12 KAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHS 76

  Fly    88 ISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDK--KDAKVMQSTISRFACRI 150
            |||||||.|.|:|||..|:.|||||:|||:||||||||.||:||.:  .|.:.:|||||||||||
Mouse    77 ISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRI 141

  Fly   151 LVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQ-DNVEIDGLTTNGVLIMHPKGSFCGGNAKCGL 214
            :..|..|..|||:|||||||:||||||||.||: .:.::|||||||||:|||:..|. .::|.|:
Mouse   142 ICERSPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFT-EDSKPGI 205

  Fly   215 WRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEK 279
            |||.||.|:||||||:|||||:|:.:..|.|.||||:||||||||||||:||||.|:||...||.
Mouse   206 WREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEA 270

  Fly   280 LIDAINAGRPQCPVGLNTLVIP--RKVNIGDQVNQPYVYLNCGHVQGHHDWG-QDENTGA-RRCP 340
            |...|||.|||||||.|||..|  ::.::.|: .||:||||||||.|:|:|| ::|..|. |.||
Mouse   271 LRQEINAARPQCPVGFNTLAFPSMKRKDVVDE-KQPWVYLNCGHVHGYHNWGNKEERDGKDRECP 334

  Fly   341 MCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCA 405
            ||..:||.|.|.:|.|..||||.|.||:||:||||:.:|||..||:.:.:||||:.|.|.|||||
Mouse   335 MCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCA 399

  Fly   406 TPLDGATGYIKLIFQDNLD 424
            ..|.|..|||:||||..||
Mouse   400 HQLAGEQGYIRLIFQGPLD 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pli	NP_001097890.1	Pellino	21..424	CDD:398402	245/407 (60%)
Peli1	NP_075813.2	Pellino	10..418	CDD:282553	245/407 (60%)
Peli1	NP_075813.2	Ring-like domain, necessary for ubiquitination of RIPK3. /evidence=ECO:0000250\|UniProtKB:Q96FA3	311..399		48/87 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835920
Domainoid	1	1.000	498	1.000	Domainoid score	I353
eggNOG	1	0.900	-	-		E1_KOG3842
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1362
Isobase	1	0.950	-	0	Normalized mean entropy	S2993
OMA	1	1.010	-	-		QHG48577
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001485
OrthoInspector	1	1.000	-	-		otm44208
orthoMCL	1	0.900	-	-		OOG6_104184
Panther	1	1.100	-	-	O	PTHR12098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4716
SonicParanoid	1	1.000	-	-		X944
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740