DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pli and Peli1

DIOPT Version :10

Sequence 1:NP_524466.1 Gene:Pli / 42821 FlyBaseID:FBgn0025574 Length:424 Species:Drosophila melanogaster
Sequence 2:NP_075813.2 Gene:Peli1 / 67245 MGIID:1914495 Length:418 Species:Mus musculus


Alignment Length:409 Identity:247/409 - (60%)
Similarity:309/409 - (75%) Gaps:9/409 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 KPRLRYGELVILGYNGYLPQGDRGRRRSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHS 87
            |..::||||::|||||.||.||||||:|:|.|.||.:|:|||.|..:|..:||.:|||.:.:|||
Mouse    12 KAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHS 76

  Fly    88 ISYTLSRNQAVIVEYKEDTETDMFQVGRSSESPIDFVVMDTLPGDK--KDAKVMQSTISRFACRI 150
            |||||||.|.|:|||..|:.|||||:|||:||||||||.||:||.:  .|.:.:|||||||||||
Mouse    77 ISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRI 141

  Fly   151 LVNRCEPAKARIFAAGFDSSRNIFLGEKATKWQ-DNVEIDGLTTNGVLIMHPKGSFCGGNAKCGL 214
            :..|..|..|||:|||||||:||||||||.||: .:.::|||||||||:|||:..|. .::|.|:
Mouse   142 ICERSPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFT-EDSKPGI 205

  Fly   215 WRECSVGGDVFSLRESRSAQQKGQPIYDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEK 279
            |||.||.|:||||||:|||||:|:.:..|.|.||||:||||||||||||:||||.|:||...||.
Mouse   206 WREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEA 270

  Fly   280 LIDAINAGRPQCPVGLNTLVIP--RKVNIGDQVNQPYVYLNCGHVQGHHDWG-QDENTGA-RRCP 340
            |...|||.|||||||.|||..|  ::.::.|: .||:||||||||.|:|:|| ::|..|. |.||
Mouse   271 LRQEINAARPQCPVGFNTLAFPSMKRKDVVDE-KQPWVYLNCGHVHGYHNWGNKEERDGKDRECP 334

  Fly   341 MCLELGPVVTLCMGLEPAFYVDVGAPTYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCA 405
            ||..:||.|.|.:|.|..||||.|.||:||:||||:.:|||..||:.:.:||||:.|.|.|||||
Mouse   335 MCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCA 399

  Fly   406 TPLDGATGYIKLIFQDNLD 424
            ..|.|..|||:||||..||
Mouse   400 HQLAGEQGYIRLIFQGPLD 418

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PliNP_524466.1 Pellino 21..424 CDD:461403 245/407 (60%)
Peli1NP_075813.2 Pellino 10..418 CDD:461403 245/407 (60%)
Ring-like domain, necessary for ubiquitination of RIPK3. /evidence=ECO:0000250|UniProtKB:Q96FA3 311..399 48/87 (55%)

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