DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pli and PELI3

DIOPT Version :9

Sequence 1:	NP_001097890.1	Gene:	Pli / 42821	FlyBaseID:	FBgn0025574	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_659502.2	Gene:	PELI3 / 246330	HGNCID:	30010	Length:	469	Species:	Homo sapiens

Alignment Length:	448	Identity:	223/448 - (49%)
Similarity:	292/448 - (65%)	Gaps:	36/448 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SPILAEDGGDGH--DKPRLRYGELVILG------------------------YNGYLPQGDRGRR 48
            |.:|:..|.|..  ::| ::||||::||                        |||.|..||:|||
Human    25 SCVLSSPGEDAQPGEEP-IKYGELIVLGCCEEGGEETEAQRGEVTGPRAHSCYNGCLASGDKGRR 88

  Fly    49 RSKFVLHKRTEASGVKRSKHYIVQSPQTSKAILDANQHSISYTLSRNQAVIVEYKEDTETDMFQV 113
            ||:..|.:|:.|:|||....:.:.:|..|||:.:..||||||||||:.:|||||..|::|||||:
Human    89 RSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQI 153

  Fly   114 GRSSESPIDFVVMDTLP-GDKKDAKVMQSTISRFACRILVNRCEPAKARIFAAGFDSSRNIFLGE 177
            |||:|:.|||||.||.| |...:....||||||:|||||.:|..|..|||:|||||:|.||||||
Human   154 GRSTENMIDFVVTDTSPGGGAAEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGE 218

  Fly   178 KATKWQ--DNVEIDGLTTNGVLIMHPKGSFCGGNAKCGLWRECSVGGDVFSLRESRSAQQKGQPI 240
            :|.||:  |.: :|||||||||:|||.|.|...:|. |:|||.||.|:|::||:||||||:|:.:
Human   219 RAAKWRTPDGL-MDGLTTNGVLVMHPAGGFSEDSAP-GVWREISVCGNVYTLRDSRSAQQRGKLV 281

  Fly   241 YDECNILQDGTLIDLCGATLLWRSAEGLQHSPTKHDLEKLIDAINAGRPQCPVGLNTLVI--PRK 303
            .:|.|:||||:||||||||||||:..||..:||...||......||.||||||||:||..  |.:
Human   282 ENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPAR 346

  Fly   304 VNIGDQVNQPYVYLNCGHVQGHHDWG--QDENTGARRCPMCLELGPVVTLCMGLEPAFYVDVGAP 366
            ........||:||:.||||.|:|.||  ::.....|.||:|..:||.|.|.:|.|....:|.|.|
Human   347 GRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPP 411

  Fly   367 TYAFNPCGHMATEKTVKYWANVEIPHGTNGFQAVCPFCATPLDGATGYIKLIFQDNLD 424
            ::||.||||:.:|||.:|||...:||||:.|.|.||||...|.|..|.::||||..||
Human   412 SHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pli	NP_001097890.1	Pellino	21..424	CDD:398402	217/435 (50%)
PELI3	NP_659502.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		4/13 (31%)
PELI3	NP_659502.2	Pellino	37..469	CDD:309722	217/434 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145848
Domainoid	1	1.000	502	1.000	Domainoid score	I343
eggNOG	1	0.900	-	-		E1_KOG3842
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	502	1.000	Inparanoid score	I1362
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48577
OrthoDB	1	1.010	-	-		D251367at33208
OrthoFinder	1	1.000	-	-		FOG0001485
OrthoInspector	1	1.000	-	-		otm42154
orthoMCL	1	0.900	-	-		OOG6_104184
Panther	1	1.100	-	-	O	PTHR12098
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4716
SonicParanoid	1	1.000	-	-		X944
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800