DRSC/TRiP Functional Genomics Resources

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Protein Alignment: CG17111 and Notch2

Sequence 1:NP_651119.2 Gene:CG17111 FlyBaseID:FBgn0039048 Length:792 Species:Drosophila melanogaster
Sequence 2:NP_077334.2 Gene:Notch2 RGDID:3188 Length:2471 Species:Rattus norvegicus

Alignment Length:582 Identity:123/583 (21%)
Similarity:172/583 (30%) Gaps:185/583 (32%)


  Fly   246 YDEEYME----NQCHERAIESD----------------NCSYELYANSSFIYAEARYLGLSQKEC 290
            |.||.::    |.|...|..||                ||.||:                  .||
  Rat  1145 YCE
EQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEV------------------DEC 1191

  Fly   291 QAMCSHEAKFYCQ--GVSFYYVNQLSLSEC------LLHSEDI--VSLGPRSLKLRENSVYMRRV 345
            |..       .||  |.....||....| |      ||..|:|  .:.||..|         ...
  Rat  1192 QNQ-------PCQNGGTCIDLVNHFKCS-CPPGTRGLLCEENIDDCAGGPHCL---------NGG 1239

  Fly   346 KCLDVRVFCTRDEMTIKYNPKDWFVGKIYASMHSKDCLARGSG---NGSVLLTLQIGSEVKENRC 407
            :|:| |:                       ..:|..||...:|   .|.:       :|...|.|
  Rat  1240 QCVD-RI-----------------------GGYSCRCLPGFAGERCEGDI-------NECLSNPC 1273

  Fly   408 ---GILRAYEMTQEYQRTFISALVVIQNNPNVQTQGDRLIKVGCIQSNATTSLGVSVRDSSVDSS 469
               |.|...::...||....||.    ...:.:|..|...:..|: :..|.::..:|.|..:...
  Rat  1274 SSEGSLDCIQLKNNYQCVCRSAF----TGRHCETFLDVCPQKPCL-NGGTCAVASNVPDGFICRC 1333

  Fly   470 EPVPSAIALESSLEYTEHMFPHEGVVHYNSSTGPHPHPSISLQILDLSHQHETNDVQIGQNLELQ 534
            .|..|....:||....: ....|..||  :::|||   ...|...|......:|..|.|.....|
  Rat  1334 PPGFSGARCQSSCGQVK-CRRGEQCVH--TASGPH---CFCLNRKDCESGCASNPCQHGGTCYPQ 1392

  Fly   535 IVAEY-----SPQQLAEHMELQLAPLPDFRATSLVAKTADNENFVLLIDERGCPTDASVFP---- 590
            ....|     ||.....|.|...||.....||.|....||.....  |.:..|.:.|..:.    
  Rat  1393 RQPPYYSCRCSPPFWGSHCESYTAPTSTPPATCLSQYCADKARDG--ICDEACNSHACQWDGGDC 1455

  Fly   591 --ALERVHTASRSMLRA----RFHAFKFSGTANVSFD--------------------VKIRFCVE 629
              .:|.......|.||.    .....:...||...||                    .|...|.:
  Rat  1456 SLTMEDPWANCTSSLRCWEYINNQCDELCNTAECLFDNFECQRNSKTCKYDKYCADHFKDNHCDK 1520

  Fly   630 RCSPSNCISSSWQRRRRQADQPDRRPEDLRVQNPVYISTVVDVAPQ-----PDNFTRSQEELPLN 689
            .|:...|   .|......||||:...|.:.|       .||.:.|:     ..:|.|:...| |:
  Rat  1521 GCNNEEC---GWDGLDCAADQPENLAEGILV-------IVVLLPPEQLLQDSRSFLRALGTL-LH 1574

  Fly   690 YNIRVHGPDQSNTNSY-LYGERGVLL-----------------IAGIDDPLHLDN-VCINQS 732
            .|:|:....|.....| .|||:...:                 |.|....|.:|| .|:..|
  Rat  1575 TNLRIKQDSQGALMVYPYYGEKSAAMKKQKVARRSLPDEQEQEIIGSKVFLEIDNRQCVQDS 1636

Known Domains:


GeneSequenceDomainRegion External IDIdentity
CG17111NP_651119.2 PAN_1 159..255 CDD:278453 4/13 (31%)
PAN_AP_HGF 270..344 CDD:238532 17/84 (20%)
Notch2NP_077334.2 EGF_CA 109..143 CDD:238011
EGF_CA 182..218 CDD:238011
EGF_CA 260..296 CDD:238011
EGF_CA 298..335 CDD:238011
EGF_CA 415..454 CDD:238011
EGF_CA 456..492 CDD:238011
EGF_CA 495..530 CDD:238011
EGF_CA 532..567 CDD:238011
EGF_CA 570..604 CDD:238011
EGF_CA 608..643 CDD:238011
EGF_CA 645..679 CDD:238011
EGF_CA 682..717 CDD:238011
EGF_CA 757..793 CDD:238011
EGF_CA 795..831 CDD:238011
EGF_CA 873..909 CDD:238011
EGF_CA 911..947 CDD:238011
EGF_CA 949..985 CDD:238011
EGF_CA 987..1022 CDD:238011
EGF_CA 1025..1061 CDD:238011
EGF_CA 1117..1147 CDD:238011 1/2 (50%)
EGF_CA 1151..1185 CDD:238011 7/34 (21%)
EGF_CA 1188..1223 CDD:238011 12/61 (20%)
EGF_CA 1225..1262 CDD:238011 11/70 (16%)
EGF_CA 1264..1302 CDD:238011 9/49 (18%)
EGF_CA <1312..1343 CDD:238011 6/32 (19%)
Notch 1423..1456 CDD:278494 8/35 (23%)
Negative regulatory region (NRR). {ECO:0000250} 1425..1677 46/226 (20%)
Notch 1463..1497 CDD:278494 7/34 (21%)
Notch 1501..1534 CDD:278494 5/36 (14%)
NOD 1540..1591 CDD:284282 13/59 (22%)
NODP 1619..1673 CDD:284987 6/19 (32%)
Ank_2 <1820..1907 CDD:289560
ANK repeat 1827..1874 CDD:293786
ANK 1 1827..1871
ANK 1872..1997 CDD:238125
ANK 2 1876..1905
ANK repeat 1877..1907 CDD:293786
Ank_2 1881..1974 CDD:289560
ANK 3 1909..1939
ANK 1938..2062 CDD:238125
ANK repeat 1943..1974 CDD:293786
ANK 4 1943..1972
Ank_2 1948..2040 CDD:289560
ANK repeat 1976..2007 CDD:293786
ANK 5 1976..2005
ANK repeat 2009..2040 CDD:293786
ANK 6 2009..2038
DUF3454 2381..2439 CDD:288764
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 FOG0000109
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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