Protein Alignment CG17121 and HSD11B1

DIOPT Version :9

• Sequence 1: NP_651114.1
• Gene: CG17121 / 42721
• FlyBaseID: FBgn0039043
• Length: 361
• Species: Drosophila melanogaster
• Sequence 2: NP_001193670.1
• Gene: HSD11B1 / 3290
• HGNCID: 5208
• Length: 292
• Species: Homo sapiens
• Alignment Length: 308
• Identity: 86/308 - (27%)
• Similarity: 149/308 - (48%)
• Gaps: 47/308 - (15%)

  Fly    63 LLPLVLLAVFLKHLLDYLFALG--LKEKDVSGKVALVTGGGSGLGREICLELARRGCKLAVVDVN 125
            |||  :|.:|:.:   |.::..  .:.:.:.||..:|||...|:|||:...||:.|..: ||...
Human     8 LLP--ILGLFMAY---YYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHV-VVTAR 66

  Fly   126 SKGCYETVELLSK-IPRCV----AKAY-----KNDVSSPRELQLMAAKVEKELGPVDILVNNASL 180
            ||      |.|.| :..|:    |.|:     ..|::...:....|.|:   :|.:|:|:.|
Human    67 SK------ETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKL---MGGLDMLILN--- 119

  Fly   181 MPMTSTP-SLKSDEIDTI---LQLNLGSYIMTTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGI 241
             .:|:|. :|..|:|..:   :::|..||::.|...|| |:.:.:|.:|.|::|||.|..|....
Human   120 -HITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAA 182

  Fly   242 YTATKYGIEGFMESLRAELRLSDCDYVRTTVANAYLMRTSGDLPLLSDAGIAKSYPGLPTPYVAE 306
            |:|:|:.::||..|:|.|..:|..: |..|:....|:.|...:..:|  ||. .....|....|.
Human   183 YSASKFALDGFFSSIRKEYSVSRVN-VSITLCVLGLIDTETAMKAVS--GIV-HMQAAPKEECAL 243

  Fly   307 KIVKGVLLNERMVYVPKIFALSVW---LLRLLPTKWQDYMLLRFYHFD 351
            :|:||..|.:..||    :..|:|   |:|....|..:::....|:.|
Human   244 EIIKGGALRQEEVY----YDSSLWTTLLIRNPCRKILEFLYSTSYNMD 287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17121	NP_651114.1	DltE	91..349	CDD:223377	78/274 (28%)
		NADB_Rossmann	94..338	CDD:304358	75/260 (29%)
HSD11B1	NP_001193670.1	11beta-HSD1_like_SDR_c	32..279	CDD:187593	78/269 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3540
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860