DRSC/TRiP Functional Genomics Resources

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Protein Alignment klg and negr1

DIOPT Version :9

Sequence 1:NP_524454.2 Gene:klg / 42707 FlyBaseID:FBgn0017590 Length:545 Species:Drosophila melanogaster
Sequence 2:XP_031755650.1 Gene:negr1 / 100127726 XenbaseID:XB-GENE-987949 Length:388 Species:Xenopus tropicalis


Alignment Length:311 Identity:89/311 - (28%)
Similarity:141/311 - (45%) Gaps:28/311 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 SNVQQSAVAASTLTATLPRFLSRGHT----YRAV------VGDTLVLPCQVENLGNFVLLWRRGT 138
            ||...:||..| |...||..|..|.:    :.||      .|:|.:|.|.:|. |.....|...:
 Frog    14 SNQWLAAVILS-LCCLLPSCLPAGQSMDFQWPAVDNLVVRQGETAMLRCFLEE-GASKGAWLNRS 76

  Fly   139 NVLTASNIMVTRDERVRLIDG----YNLEISDLEPQDAGDYVCQISDKINRD--QVHTVEILVPP 197
            :::.|.....:.|.||.:...    |:|.|..::..|.|.|.|.:..:.:..  ||| :.:.|.|
 Frog    77 SIIFAGGDKWSVDPRVSIATSSKQEYSLRIQKVDVSDDGPYTCSVQTEHSPRTLQVH-LTVHVSP 140

  Fly   198 SVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWTKKSGANKSTARIGDGPILTLEKLERQQAG 262
            .:..|  |..:...:|..::|.|..:|.|.|||.|...|   .|..:.|.|..|.:..:.|.|||
 Frog   141 KIYDI--SSDMTVNEGTNVSLICLATGKPEPSISWRHIS---PSAKQFGSGQYLDIYGITRDQAG 200

  Fly   263 VYQCTADNGVGDPVTVDMRLDVLYPPDI-QVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSF 326
            .|:|:|:|.|..|....:::.|.:.|.| ::..:.:..|.  ...:.|...|.|.....||:...
 Frog   201 DYECSAENDVSFPDVKKVKVTVNFAPTILEITPTGVSLGR--TGLIRCETAAVPAPVFEWYKGEK 263

  Fly   327 PIQSTDRRIMATRAN-RHMLTIRHIQQEDFGNYSCVADNSLGRSRKYMELS 376
            .:.:..|.|.....| |.:||:.::.:|.||||:|||.|.||.|...:.|:
 Frog   264 KLTNGQRGIRIQNYNTRSILTVSNVTEEHFGNYTCVAVNKLGTSNASLPLN 314

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klgNP_524454.2 DUF1370 63..>124 CDD:284518 16/49 (33%)
IG_like 109..195 CDD:214653 23/101 (23%)
Ig 118..191 CDD:143165 19/78 (24%)
IG_like 205..274 CDD:214653 24/68 (35%)
IGc2 213..273 CDD:197706 22/59 (37%)
IGc2 301..367 CDD:197706 20/66 (30%)
FN3 392..486 CDD:238020
negr1XP_031755650.1 Ig 44..136 CDD:416386 23/93 (25%)
FR1 44..62 CDD:409353 5/17 (29%)
Ig strand A' 47..53 CDD:409353 0/5 (0%)
Ig strand B 55..63 CDD:409353 3/7 (43%)
CDR1 63..68 CDD:409353 2/5 (40%)
FR2 69..75 CDD:409353 1/5 (20%)
Ig strand C 69..74 CDD:409353 1/4 (25%)
CDR2 76..87 CDD:409353 1/10 (10%)
Ig strand C' 78..82 CDD:409353 0/3 (0%)
Ig strand C' 84..87 CDD:409353 0/2 (0%)
FR3 88..122 CDD:409353 10/33 (30%)
Ig strand D 91..98 CDD:409353 2/6 (33%)
Ig strand E 101..107 CDD:409353 2/5 (40%)
Ig strand F 114..122 CDD:409353 3/7 (43%)
CDR3 123..127 CDD:409353 0/3 (0%)
Ig strand G 127..136 CDD:409353 3/9 (33%)
FR4 129..136 CDD:409353 3/7 (43%)
Ig_3 140..208 CDD:404760 24/72 (33%)
Ig strand A' 146..151 CDD:409353 1/4 (25%)
Ig strand B 157..164 CDD:409353 2/6 (33%)
Ig strand C 170..175 CDD:409353 3/4 (75%)
Ig strand C' 177..179 CDD:409353 1/4 (25%)
Ig strand E 187..193 CDD:409353 1/5 (20%)
Ig strand F 200..207 CDD:409353 3/6 (50%)
Ig strand G 214..222 CDD:409353 0/7 (0%)
Ig_3 226..302 CDD:404760 22/77 (29%)
putative Ig strand A 226..232 CDD:409353 2/5 (40%)
Ig strand B 242..246 CDD:409353 0/3 (0%)
Ig strand C 255..259 CDD:409353 0/3 (0%)
Ig strand E 281..285 CDD:409353 1/3 (33%)
Ig strand F 295..300 CDD:409353 3/4 (75%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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