DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and Pxdn

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	XP_006515268.1	Gene:	Pxdn / 69675	MGIID:	1916925	Length:	1503	Species:	Mus musculus

Alignment Length:	830	Identity:	264/830 - (31%)
Similarity:	384/830 - (46%)	Gaps:	181/830 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PSFFFVVNGSDSELAPNRPLP------DEPAAEWALQQAALGHHDGAQAVSAGIKALGDREILEE 138
            |.|..:.:....|:..|..||      .|||..|        :.||.|...:     |...|..|
Mouse   550 PVFASIPSDMTVEVGTNVQLPCSSQGEPEPAITW--------NKDGVQVTES-----GKFHISPE 601

  Fly   139 G-LQPNEVNTPSFRHYRSLSTN---------------PEARKLARRG-------YVENQATI--- 177
            | |..|:|.|.....|..::.|               |:   ::|.|       .||..||:
Mouse   602 GFLTINDVGTADAGRYECVARNTIGYASVSMVLSVNVPD---VSRNGDPYVATSIVEAIATVDRA 663

  Fly   178 -----------------DIAKRFNYTKQP---GRSNIGWGPKIV--------------------- 201
                             |:...|.|.:.|   |::..|   :|.
Mouse   664 INSTRTHLFDSRPRSPNDLLALFRYPRDPYTVGQARAG---EIFERTLQLIQEHVQHGLMVDLNG 725

  Fly   202 -------LPDPTVLRL--------------ECD---FNARYRRSTGVCNNKQHPRTYGASMVPYR 242
                   |..|..|.|              .|.   |:.:||...|.|||.||| .:|||:..:.
Mouse   726 TSYHYNDLVSPQYLSLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHP-MWGASLTAFE 789

  Fly   243 RMVSPDYADGIAAPRVSHHGR------LPPARQVSLKIHRSSYET-DSNFTVMLAVFGQFMDHDI 300
            |::...|.:|...||..:..|      ||..|.||..:..:...| |..||.||..:|||:|||:
Mouse   790 RLLKAVYENGFNTPRGINSQRQYNGHVLPMPRLVSTTLIGTEVITPDEQFTHMLMQWGQFLDHDL 854

  Fly   301 TATSLTTSQ----EGESIDCCVAATREQHPECYPVDILPDDPYYKQYNISCMNFVRSAP-APTGR 360
            .:|.:..||    :|:  .|....:.:  |.|:.|.|.|:||..:. ...||.||||:| ..:|.
Mouse   855 DSTVVALSQARFSDGQ--HCSSVCSND--PPCFSVMIPPNDPRVRS-GARCMFFVRSSPVCGSGM 914

  Fly   361 FG-------PRMQLNQATAFIDASVVYGNLEQRQNQLRSFIN--GSLRM-FVTDDGRQLLPISSN 415
            ..       ||.|:||.|::||||.|||:.:.....:|...:  |.||. .|...|:.|||.::.
Mouse   915 TSLLMNSVYPREQINQLTSYIDASNVYGSTDHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATG 979

  Fly   416 PADGCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEA 480
            |...|.|.: ......||.:||.||||.|.|||||.||.|.||.:|.:|.:.||||:.:.:|.|.
Mouse   980 PPTECMRDE-NESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIAAELLKLNPHWDGDTVYHET 1043

  Fly   481 RKILGAQMAHITYNEFLPVLLG----KNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAF 541
            |||:||::.||||..:||.:||    |.:.|.:|             |||.|:..|.|.||.|||
Mouse  1044 RKIVGAEIQHITYRHWLPKILGEVGMKMLGEYRG-------------YDPSVNAGIFNAFATAAF 1095

  Fly   542 RFAHTLL-PGLFNISRD-NSTPEA-IELHKMLFNPFSLWAEHGID---HALMTAANTPVMQV-DR 599
            ||.|||: |.|:.:..: ...|:. :.|||..|:||.:..|.|||   ..|...|..  |:: .:
Mouse  1096 RFGHTLINPLLYRLDENFEPIPQGHVPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGK--MRIPSQ 1158

  Fly   600 FFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAID 664
            ..:.|:|::||     .......|||.::|||||||||||.|..:|.:|.|....|:|::...|.
Mouse  1159 LLNTELTERLF-----SMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEIK 1218

  Fly   665 NATL-DSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQ 728
            :..: :.::::|.|..::|::...:.|..:.|:..||.|.|::|.||.||:.||..|||   .|.
Mouse  1219 SPVIREKLQRLYGSTLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWYE---NPG 1280

  Fly   729 KFTKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNPHVDCQDL 778
            .|:.|||.::.:||||.|:|.|||.||||::.|. |:.:..:.:..|:|:
Mouse  1281 VFSPAQLTQLKQTSLARILCDNSDNITRVQQDVF-RVAEFPHGYSSCEDI 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	213/570 (37%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	154/400 (39%)
Pxdn	XP_006515268.1	leucine-rich repeat	94..112	CDD:275380
		leucine-rich repeat	113..127	CDD:275378
		LRR_8	115..171	CDD:338972
		LRR_8	160..219	CDD:338972
		leucine-rich repeat	161..184	CDD:275378
		leucine-rich repeat	185..208	CDD:275378
		leucine-rich repeat	209..221	CDD:275378
		TPKR_C2	217..268	CDD:387596
		I-set	271..358	CDD:369462
		I-set	367..454	CDD:369462
		Ig3_Peroxidasin	471..544	CDD:143222
		Ig4_Peroxidasin	567..635	CDD:143223	19/80 (24%)
		peroxidasin_like	889..1328	CDD:188658	176/464 (38%)
		VWC	1439..1494	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820