DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cd and pxn-1

DIOPT Version :10

Sequence 1:NP_651081.1 Gene:cd / 42681 FlyBaseID:FBgn0263986 Length:830 Species:Drosophila melanogaster
Sequence 2:NP_505188.3 Gene:pxn-1 / 191484 WormBaseID:WBGene00004256 Length:1285 Species:Caenorhabditis elegans


Alignment Length:908 Identity:263/908 - (28%)
Similarity:389/908 - (42%) Gaps:237/908 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LPP--YQGPERVFPGGVSPRARRNKMRQFQCCMGITFIAIVFTALCLALVFSDSLGGADGGPSFF 83
            :||  |:||:.|                                       |.:|||     |..
 Worm   406 VPPNIYEGPQSV---------------------------------------SQNLGG-----SVV 426

  Fly    84 FV--VNGSDSELAPNRPLPDEPAAEWALQQAALGHHDGAQAVSAGIKALGDREILEEG--LQPNE 144
            ||  .||:        |:||   ..|:...:.:||..|...||            ::|  |:.:.
 Worm   427 FVCKANGN--------PVPD---YTWSFDGSTIGHIKGRFMVS------------DDGTELRISN 468

  Fly   145 VNTPSFRHYRSLSTNP---------------EARKLA---------------RRGYVENQA---- 175
            :......:|..::.||               |.||.|               .|..|||..    
 Worm   469 IEKKDEGYYSCMAGNPVGAMSADAKLTVIGGETRKAAAPQIDEELLRAIAQKARQNVENAVEKTR 533

  Fly   176 ----------TIDIAK--RFNYTKQP----------------GRSNIGWG---------PKIVLP 203
                      |.|:.:  ||:..||.                .|.::..|         ||.|..
 Worm   534 KQLTQDKVTNTNDLKRLFRFSTPKQAVELSKAREIYEESVRLVREHVEKGLILNVDELHPKNVSY 598

  Fly   204 DPTVLRL----------------------ECDFNARYRRSTGVCNNKQHPRTYGASMVPYRRMVS 246
            : :||.:                      :..|:.|||...|.||||..|.| |.|::|.||::.
 Worm   599 E-SVLHVTHVQALMGLSGCHTGQYKNPCTDTCFHHRYRSFDGQCNNKNKPMT-GVSLMPLRRLLK 661

  Fly   247 PDYADGIAAPRVSHHGR------LPPARQVSLKIHRSSYET-DSNFTVMLAVFGQFMDHDITATS 304
            |.|.:|...|.....||      ||..|:||.::..:...| .|..:.|:..:|||:|||:|.|.
 Worm   662 PVYENGFNTPVGWEKGRLYNGYPLPNVREVSRQLVATENITPHSKLSSMVMQWGQFVDHDLTHTV 726

  Fly   305 LTTSQEGESIDCCVAATREQHPECYPVDILPDDPYYKQYNIS--CMNFVRSAPAPTG-------- 359
            ...|:...:.......|.|....|:.:.:.|:||..|..:..  |:.|.||| |..|        
 Worm   727 TALSRHSYATGAFCNRTCENLDPCFNIPLSPNDPRVKSGSAKYPCIEFERSA-AVCGSGETSLVF 790

  Fly   360 -RFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFI--NGSLRMFVTDD-GRQLLPISSNPADGC 420
             |...|.|:|..|:|:|||.|||:.|.:..:||...  ||.||..:|.: |::.||...:....|
 Worm   791 NRVTYREQMNALTSFLDASNVYGSNEVQAQELRDTYNNNGMLRFDITSEAGKEYLPFEKDSNMDC 855

  Fly   421 NRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILG 485
            .|.........||.:||.||||.|.|.:.|.::.|.||.:|::|:..|.:|:.|.:|.|.|||:|
 Worm   856 RRNFSEENPIRCFLAGDLRANEQLALAATHTIFIREHNRIAKKLKSMNGNWDGEIIYHETRKIVG 920

  Fly   486 AQMAHITYNEFLPVLLG------KNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFA 544
            |.|.||||..::|::.|      |.:...:|             |||:||.|:.|.||.|||||.
 Worm   921 AMMQHITYKHWMPIIFGGQAQMNKFVGTYQG-------------YDPDVDASVTNAFATAAFRFG 972

  Fly   545 HTLL-PGLFNISRDNSTPEA--IELHKMLFNPFSLWAEHGIDHALMTAANTPVM--QVDRFFSLE 604
            ||:: |.||.:..|....:.  |.|||..|.|..:..:.|:|..|.....:|:.  ...:..::|
 Worm   973 HTIINPSLFRLGNDFMPIKEGHIALHKAFFTPELVLTQGGVDPLLRGLFASPLKHPMPTQLLNME 1037

  Fly   605 VTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAI-DNATL 668
            :.:|||....|     ..|||..:||||.||||:|||..:|:.|.||....||:|...| |:..:
 Worm  1038 LIEKLFMKGHE-----VSLDLAVMNIQRSRDHGLPSYTEYRKFCNLPVPVQWEDMKGYIKDDMII 1097

  Fly   669 DSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKA 733
            ..:|.:|..||::|::.|.:.|..|:..:|||..:|::.:||.:::.||..|||:   ...||..
 Worm  1098 QKLRGLYGVPQNIDLWVGGIVEEKLENGLFGPTFACIIGEQFRKIRDGDRFWYEK---DGVFTPE 1159

  Fly   734 QLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNPHVD------CQDLEGFHFNFEPWSE 790
            ||.||.|.:||.:.|.|.|.|.|:::.|..      .|.:|      ||:.|  ..|...||:
 Worm  1160 QLREIKKITLARLFCDNGDNIDRIQKDVFM------YPGMDKENYGTCQETE--MMNLRAWSK 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cdNP_651081.1 An_peroxidase 218..762 CDD:460804 202/576 (35%)
pxn-1NP_505188.3 LRR <35..>174 CDD:443914
leucine-rich repeat 35..53 CDD:275380
leucine-rich repeat 54..77 CDD:275380
leucine-rich repeat 78..101 CDD:275380
leucine-rich repeat 102..117 CDD:275380
leucine-rich repeat 125..148 CDD:275380
leucine-rich repeat 149..172 CDD:275380
PCC 153..>267 CDD:188093
I-set 315..400 CDD:400151
Ig strand B 332..336 CDD:409353
Ig strand C 345..349 CDD:409353
Ig strand E 368..372 CDD:409353
Ig strand F 382..387 CDD:409353
Ig strand G 395..398 CDD:409353
IG_like 414..496 CDD:214653 25/148 (17%)
Ig strand B 425..429 CDD:409353 1/3 (33%)
Ig strand C 438..442 CDD:409353 1/6 (17%)
Ig strand E 461..466 CDD:409353 2/4 (50%)
Ig strand F 476..481 CDD:409353 1/4 (25%)
Ig strand G 489..492 CDD:409353 0/2 (0%)
peroxidasin_like 757..1203 CDD:188658 166/473 (35%)
Blue background indicates that the domain is not in the aligned region.

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