DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and Epx

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_031972.2	Gene:	Epx / 13861	MGIID:	107569	Length:	716	Species:	Mus musculus

Alignment Length:	697	Identity:	235/697 - (33%)
Similarity:	337/697 - (48%)	Gaps:	111/697 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 ALGDREILEEGLQPNEVNTPSFRHYRS--LSTNPEARKLARRGYVENQATIDIAKRFNYTKQPGR 191
            |||   :|||.|||.     ..|.:.:  :.|.|:.|.|::   ....|..|.|:|
Mouse    97 ALG---LLEERLQPR-----GSRPFNATDVLTEPQLRLLSQ---ASGCALQDQAER--------- 141

  Fly   192 SNIGWGPKIVLPDPTVLRLECDFNARYRRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAP 256
                                |  :.:||..||.||||:|| ..|||.....|.:..:|.|..:.|
Mouse   142 --------------------C--SNKYRTITGRCNNKKHP-WLGASNQALARWLPAEYEDHRSLP 183

  Fly   257 RVSHHGR------LPPARQVSLKIHR---SSYETDSNFTVMLAVFGQFMDHDITATSLTTSQEGE 312
            .....|:      ||..|.||.:|.|   ....:|....:|...:|||:|||:..:..:.::...
Mouse   184 FGWTPGKRRNGFLLPLVRDVSNQIVRFPSKKLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAF 248

  Fly   313 S--IDCCVAATREQHPECYPVDILPDDPYYKQYNISCMNFVRSAPA-PTGRFGPRMQLNQATAFI 374
            |  :||  ..|..|.|.|:|:.|..:||..|... .|:.|.||||| |..|...|.|:|..|:|:
Mouse   249 SMGVDC--EKTCAQLPPCFPIKIPRNDPRIKNQR-DCIPFFRSAPACPQNRNKVRNQINALTSFV 310

  Fly   375 DASVVYGNLEQRQNQLRSFINGSLRMFVT-----DDGRQLLPISSNPADGC---NRVQMTRLGKY 431
            |||:|||:......:||:..| .|.:..|     |:||.|||..:...|.|   ||  ..|:.
Mouse   311 DASMVYGSEVTLALRLRNRTN-FLGLLATNQRFQDNGRALLPFDNLHEDPCLLTNR--SARIP-- 370

  Fly   432 CFESGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEF 496
            ||.:||.|::|...||::|.|:.|.||.||.:|:..||||..::||.|||||:||.:..|||.:|
Mouse   371 CFLAGDTRSSETPKLTALHTLFVREHNRLAAELRRLNPHWSGDKLYNEARKIVGAMVQIITYRDF 435

  Fly   497 LPVLLGKNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAHTLL-PGLFNIS---RD 557
            ||::||:        ...:..|.....|...|||.:||.| ..||||.||:| |.:|.:.   |.
Mouse   436 LPLVLGR--------ARIRRTLGPYRGYCSNVDPRVANVF-TLAFRFGHTMLQPFMFRLDSQYRA 491

  Fly   558 NSTPEAIELHKMLFNPFSLWAEHGIDHALMTAANTPV-------MQVDRFFSLEVTQKLFEGTAE 615
            ::....:.|..:.|..:.:..|.|||..|.....||.       |.||     |:..|||:
Mouse   492 SAPNSHVPLSSVFFASWRIIHEGGIDPILRGLMATPAKLNRQDSMLVD-----ELRDKLFQ---- 547

  Fly   616 DRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAIDNATL-DSIRQIYESPQ 679
             :|...||||.:||:||.||||:|.|..:||.|.|.......::|:.:.|..| ....::|::|.
Mouse   548 -QVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLRLYKTPD 611

  Fly   680 DVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKTSLA 744
            ::|::.||::||.|.||..||||:|:..:||.|.:.||..|:: |.|  .|||.|...:.:.||:
Mouse   612 NIDIWVGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQ-KWG--VFTKRQRKALRRISLS 673

  Fly   745 AIICRNSDGITRVREHVMQRLRDGGNPHVDCQDLEGFHFNFEPWSEK 791
            .|:|.|: |||.|...:. |........|.|..:.  ..|...|..|
Mouse   674 RIVCDNT-GITTVSRDIF-RANIYPQGFVSCSRIP--KLNLSAWRGK 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	207/568 (36%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	151/405 (37%)
Epx	NP_031972.2	An_peroxidase	146..684	CDD:281139	208/569 (37%)
Epx	NP_031972.2	myeloperoxidase_like	288..700	CDD:188656	163/440 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2576
Isobase	1	0.950	-	0	Normalized mean entropy	S5081
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820