DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and PXDNL

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_653252.4	Gene:	PXDNL / 137902	HGNCID:	26359	Length:	1463	Species:	Homo sapiens

Alignment Length:	932	Identity:	270/932 - (28%)
Similarity:	406/932 - (43%)	Gaps:	188/932 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PYQGPERVFPGGV--SPRARRNKMRQFQC----CMGITFIAIVFTALCLALVFSDSLGGADGGPS 81
            |.:|...|...|.  ..||.::...|::|    .:|:..:::..|....||.....|      |.
Human   460 PVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQL------PQ 518

  Fly    82 FFFVVNGSDSELAPNRPLPDEPAAEWALQQAALGHHDGAQAVSAG-------------------- 126
            ...|..|.:..::.:.....:|...|        :.:|.|...:|
Human   519 DTSVEVGKNINISCHAQGEPQPIITW--------NKEGVQITESGKFHVDDEGTLTIYDAGFPDQ 575

  Fly   127 ---------------------IKALGDRE---------ILEEGLQPNEVNTPSFRHYRSLSTNPE 161
                                 :.|:..|:         ||:...:.:.....:.||..|...:..
Human   576 GRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTS 640

  Fly   162 ARKLARRGYVENQATIDIAKR---FNYTKQPGRSNIGWGPKIVLP----------DPTVLRL--- 210
            :..||:..|..:...:::|:.   |.:|.|..|..:..|..:.|.          .|..|.|
Human   641 SDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIAN 705

  Fly   211 -----------ECD---FNARYRRSTGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAPR---- 257
                       .|.   |:|:||...|.|||.|.| |:||::..:.|::.|.|.|||.|||
Human   706 LSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQP-TWGAALTAFARLLQPAYRDGIRAPRGLGL 769

  Fly   258 -VSHHGRLPPARQVSLKIHRSSYET-DSNFTVMLAVFGQFMDHDI--TATSLTTSQEGESIDCCV 318
             |.....|||.|.|:....|::..| |.::|.||..:|.|::||:  |..:|:|::..:...|..
Human   770 PVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSS 834

  Fly   319 AATREQHPECYPVDILPDDPYYKQYNISCMNFVRSAPA-PTGRFGP---------RMQLNQATAF 373
            ..|.:  |.|:|::....||  :..:..||.|.||:|| .:||  |         |.|:||.||:
Human   835 VCTND--PPCFPMNTRHADP--RGTHAPCMLFARSSPACASGR--PSATVDSVYAREQINQQTAY 893

  Fly   374 IDASVVYGNLEQRQNQLR--SFINGSLRMFV--TDDGRQLLPISSNPADGCNRVQMTRLGKYCFE 434
            ||.|.|||:.|:....||  |...|.|:...  ...|:.|||.|:.|...|.|.:..   ..||.
Human   894 IDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQE---SPCFL 955

  Fly   435 SGDDRANENLLLTSMHLLWARHHNYLARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPV 499
            :||.||||:|.|.:||.||.|.||.:|.:|...|||||...:|||||||:||::.||||:.:||.
Human   956 AGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPK 1020

  Fly   500 LLGKNISEAKGLLPAKHNLNAPDTYDPEVDPSIANCFAAAAFRFAHTLL-PGLFNISRDNSTPEA 563
            :||.         |....|.....|:|.|:..|.|.||.|||||.|||: |.|:.:   |:|...
Human  1021 VLGD---------PGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRL---NATLGE 1073

  Fly   564 IE-----LHKMLFNPFSLWAEHGIDHALMTAANTPVMQ-----------VDRFFSLEVTQKLFEG 612
            |.     .||.||:|..:..|.|||         ||::           .....|.|:||:||..
Human  1074 ISEGHLPFHKALFSPSRIIKEGGID---------PVLRGLFGVAAKWRAPSYLLSPELTQRLFSA 1129

  Fly   613 TAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHCRLPTVDTWEEMSQAI-DNATLDSIRQIYE 676
            ...     ..:|..:..||||||||||.|..||..|.|.:|..:|::...| |:.....:|::|.
Human  1130 AYS-----AAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYG 1189

  Fly   677 SPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLRLKLGDSHWYERKMGPQKFTKAQLAEIYKT 741
            ||.|:|::...:.|..:.|...||.|.|:...||.||:.||..|||   .|..||.|||.::.:.
Human  1190 SPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYE---NPGVFTPAQLTQLKQA 1251

  Fly   742 SLAAIICRNSDGITRVREHVMQRLRDGGNPHVDCQDLEGFHFNFEPWSEKQQPQDLHSAGISRGS 806
            ||:.::|.|.|.|.:|:..|..: .:....:::|.::.  ..:...|      ||..:...|||.
Human  1252 SLSRVLCDNGDSIQQVQADVFVK-AEYPQDYLNCSEIP--KVDLRVW------QDCCADCRSRGQ 1307

  Fly   807 TSVRVMSKANHQAHNVTLHIDK 828
            ...........::...:..:||
Human  1308 FRAVTQESQKKRSAQYSYPVDK 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	214/576 (37%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	156/407 (38%)
PXDNL	NP_653252.4	LRR 1	51..72
		leucine-rich repeat	52..85	CDD:275378
		LRR_8	53..134	CDD:316378
		LRR 2	75..96
		leucine-rich repeat	86..123	CDD:275378
		LRR 3	99..120
		LRR_8	123..182	CDD:316378
		LRR 4	123..144
		leucine-rich repeat	124..147	CDD:275378
		LRR 5	147..168
		leucine-rich repeat	148..171	CDD:275378
		leucine-rich repeat	172..184	CDD:275378
		LRRCT	180..232	CDD:214507
		Ig_3	234..309	CDD:316449
		Ig_3	329..402	CDD:316449
		Ig	432..505	CDD:325142	9/44 (20%)
		Ig	528..596	CDD:325142	5/75 (7%)
		peroxidasin_like	851..1286	CDD:188658	174/471 (37%)
		VWC	1400..1450	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820