Protein Alignment Efa6 and GEA2

DIOPT Version :10

• Sequence 1: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: NP_010892.1
• Gene: GEA2 / 856691
• SGDID: S000000748
• Length: 1459
• Species: Saccharomyces cerevisiae
• Alignment Length: 527
• Identity: 111/527 - (21%)
• Similarity: 197/527 - (37%)
• Gaps: 136/527 - (25%)

  Fly  1125 VESLHSYHYSPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSK-----NNDFSR----------- 1173
            :|..::::..||. .:|..|.        .||..||..:.:::     ||..::
Yeast   564 IECTNAFNEKPKK-GIPMLIE--------KGFIASDSDKDIAEFLFNNNNRMNKKTIGLLLCHPD 619

  Fly  1174 --AVADEYLKHFTFEKKSLDQALREFLQQFSLSGETQERERVLVHFSKRFL---DCNPGTF--NS 1231
              ::.:||::.|.|....:|:|:|..|.:|.|.||:|:.||::..||..:.   |.:|...  |:
Yeast   620 KVSLLNEYIRLFDFSGLRVDEAIRILLTKFRLPGESQQIERIIEAFSSAYCENQDYDPSKISDNA 684

  Fly  1232 QDAVHT----------LTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLNDGENFPKDVLKSLYQ 1286
            :|.:.|          |:.:|::||||||...:...||..::..||....:.::||...|..:|.
Yeast   685 EDDISTVQPDADSVFILSYSIIMLNTDLHNPQVKEHMSFEDYSGNLKGCCNHKDFPFWYLDRIYC 749

  Fly  1287 AIKTKPLEWALDEEAGDLQQQRANNSALGNV-----------GLNPFLDPPELAT---AVEYKKG 1337
            :|:.|.:....:....:...:.|.|:.:.:.           .:...|.|.||..   |:..:.|
Yeast   750 SIRDKEIVMPEEHHGNEKWFEDAWNNLISSTTVITEIKKDTQSVMDKLTPLELLNFDRAIFKQVG 814

  Fly  1338 ----------YVMRKCCYDSSFKKTPFGKRSWKMFYCTLRD--------------LVLYLHKDE- 1377
                      ||:....:.|:...|...|.|:...:...:|              |:...|.||
Yeast   815 PSIVSTLFNIYVVASDDHISTRMITSLDKCSYISAFFDFKDLFNDILNSIAKGTTLINSSHDDEL 879

  Fly  1378 --HGFRKSQM--------SDNLH-----NAIRIHHALATKANDYTKKQHVFRLQTADQAEYLFQT 1427
              ..|....|        ..|..     :|:|...:...:.|...    .||:...::...:|
Yeast   880 STLAFEYGPMPLVQIKFEDTNTEIPVSTDAVRFGRSFKGQLNTVV----FFRIIRRNKDPKIF-- 938

  Fly  1428 SDSKELQSWVETINYVCA----AISAPPLEGGVGSQKRFQRPLLP----------SKQSKLMLKE 1478
              ||||  |:..:|.:..    .|.:|.:...:  |||.:...||          ||:||.:|..
Yeast   939 --SKEL--WLNIVNIILTLYEDLILSPDIFPDL--QKRLKLSNLPKPSPEISINKSKESKGLLST 997

  Fly  1479 QLDSHEVQLAQLDQELNEHKKGP--IPSKGLALQNYKEKESYLQYELRRYRTYVSILSAKMLADQ 1541
            .....:......::|:...||..  |.|..:|...: ..||.:..:|           .|.|.|.
Yeast   998 FASYLKGDEEPTEEEIKSSKKAMECIKSSNIAASVF-GNESNITADL-----------IKTLLDS 1050

  Fly  1542 QQLELQA 1548
            .:.|..|
Yeast  1051 AKTEKNA 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	51/200 (26%)
		PH_EFA6	1330..1452	CDD:270107	30/168 (18%)
GEA2	NP_010892.1	Sec7_N	350..489	CDD:463703
		Sec7	559..756	CDD:460178	51/200 (26%)