Protein Alignment Efa6 and SYT1

DIOPT Version :10

• Sequence 1: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: NP_015420.1
• Gene: SYT1 / 856210
• SGDID: S000006299
• Length: 1226
• Species: Saccharomyces cerevisiae
• Alignment Length: 725
• Identity: 144/725 - (19%)
• Similarity: 270/725 - (37%)
• Gaps: 201/725 - (27%)

  Fly   752 NRSSSSSSNSSDNNNCSSNTGEPATSETATATATIITATSTRTMNCSSKLNYILCKKASDRDRIV 816
            :.|:..:.|....:|.|:...:...||:..:....:......|.|...||:...|:
Yeast    16 SHSNDKNGNKKGGSNVSTGIDKLRESESYRSPFLQLAEIQEHTNNDDDKLDVKECE--------- 71

  Fly   817 WTYNAPLQPH-QLAALQRQQQQQEQQFQQQQQQ-------LHQQHLQQQQQLQQQ-HQQQQQQQQ 872
                 |.:.| :|:.::|:..:.:..|:...::       |..|||:..|..::. .:.:.....
Yeast    72 -----PTKKHSKLSRIRRKMGRLDLNFRSANEKGSEDDEILVAQHLRNGQDPEEMPFKSENNIDS 131

  Fly   873 QQQQQQLYGQQ-SHSNSHSSSISSSPQHSAV------------------------------GS-- 904
            .::..:..|:: :.::|.|.::..:.:|:..                              |.
Yeast   132 IEKVPKPDGERVTLTSSGSDNVKRNSKHAPFIPVKPALEKFPSSNRLSRDYRKSQEPTLFNGDRL 196

  Fly   905 -PASPT----SVSSSVMSSSG-------SKGALGLGSSSNG-----------PMAAV-------Q 939
             |..||    |.||||.||:.       ||.|:...|||:.           |:.|.       |
Yeast   197 VPTLPTVSRISTSSSVGSSTAASRYFNPSKRAVVASSSSSSSSIKFNSLHAIPLDATPQIELAKQ 261

  Fly   940 QQQLREREQGGQVAQPPSGIPGLLSCPGGGCGNNGGGGGIGGGGNNDQSVSEAISNISSPDYQDD 1004
            |.::.:|..|.:.::.......:..       ||        ...|...:|.: |.|.:.|.::.
Yeast   262 QDEISKRRFGRRRSRTVDVFDYINK-------NN--------TAKNKPPLSPS-SFIRTIDEKNT 310

  Fly  1005 DNLLSSRDILG--GMVLSDPSDSDSTILVSDA----AAHQRQQLKQQLRAQQQQ--QRERERDRD 1061
            ::|:  :|.:|  |.:|.|    |:.|:.:|.    |:|...|:..:.|:|...  |.:..:.:.
Yeast   311 NSLM--QDPMGSRGPLLPD----DANIISNDTDGAEASHPDHQVLSRSRSQSTSFVQGKGGKRKS 369

  Fly  1062 RDREQSEHKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVE 1126
            .:.|...:|:     ||...|...:..|.:|..:         .|:|...|.:|..|:...|.|.
Yeast   370 IEDEGYHNKL-----GLPHGSGPTSVYNNKSNAN---------STITGMSRRSSSIVNALSSFVN 420

  Fly  1127 SLHSYHYSPKAVDMPSAIRLAKRLH-SLDGFKKSDVSRHLSKNNDFSRAVA-------------- 1176
            ...|...|.:...:....:|.::|. ||:...............||...:|
Yeast   421 LRSSSLSSSRQQHLQQQQQLQQKLDVSLEDLPPVPAPEFSDSCKDFLIKLAPYGKFIGIILTEKD 485

  Fly  1177 DEYLKH---------FTFEKKSLDQALREFLQQFSLSGETQERERVLVHFS------------KR 1220
            ||:.|:         |.|:...||.|||:.|....|..|||:.:|:::.||            |:
Yeast   486 DEFKKNCLNYLLTNCFEFKNDPLDIALRKLLMFLELPKETQQIDRLIMAFSFAYYKAQKSYSKKK 550

  Fly  1221 FLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLND----GENFPKDVL 1281
            .::|   .:::.|.|:.:..::::|:||....|...||:..:|||.:.  ||    |...|..||
Yeast   551 GIEC---PWSNADQVYFIAFSLLMLHTDYFNPNNKSKMTKHDFVDLVH--NDKYSGGNEIPMAVL 610

  Fly  1282 KSLYQAIKTK-----------PL---EWALDEEAGDLQQQRANNSALGNVGLNPFLDPPELATAV 1332
            ...|:.:..|           |:   :..||::|.|      .|.|: .:..|....|.::
Yeast   611 TYFYENVTAKESPKFNYFLMSPMALDDSILDKDAFD------TNFAI-TLSSNSMYSPIDM---- 664

  Fly  1333 EYKKGYVMRK 1342
             .|:|.::.|
Yeast   665 -IKRGSIIPK 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	49/219 (22%)
		PH_EFA6	1330..1452	CDD:270107	3/13 (23%)
SYT1	NP_015420.1	Sec7	443..622	CDD:214569	45/183 (25%)