Protein Alignment Efa6 and psda

DIOPT Version :10

• Sequence 1: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Sequence 2: XP_009305653.1
• Gene: psda / 570918
• ZFINID: ZDB-GENE-090313-44
• Length: 1611
• Species: Danio rerio
• Alignment Length: 1588
• Identity: 412/1588 - (25%)
• Similarity: 634/1588 - (39%)
• Gaps: 445/1588 - (28%)

  Fly   160 NSSPLLASGSTTTTTTATHTHSHSRNSS-----------ASSTKIKVVETSITTSTTNVVGLTSP 213
            :.||::.|.|.|..|.|| ...|.||||           ..|...|....:|:.||.|.
Zfish   308 SGSPVIPSSSRTLPTKAT-IMDHERNSSFYRLPRSPATDQLSHHAKQAYFTISNSTVNT------ 365

  Fly   214 TGSVGGGVGGEATSPTFRPSRIPQALTKCAVPKPVPVLHSPQNKRPRPSQIPTKAANGNGNGHTA 278
                     .|.::...:.||:...|..|   ||..:.|.      .|::|.|::.:.....|:.
Zfish   366 ---------QEISNQRVQGSRLRPNLPSC---KPTAIQHE------LPAKIVTQSPSNQQISHSM 412

  Fly   279 HLPPQSLQHSNSYSGSPVTR-QRFADREPEREPEPNSAPPQPAKAPRFEAYMMTGDLILNLSRTP 342
            ...|:.....|.:.|:..|: ::..::..|:.....:..|..|:....||..::  :::...|||
Zfish   413 SDSPRQSHRVNFHLGNSKTKAEKVVNQLSEKRSISPATSPDTARKLAEEATKLS--VLMEARRTP 475

  Fly   343 QTSNPLPAQAKKIDSLRDSPSRLVNPRINGALAPRASGESSPTSSSSVDSPTNTSSDSVKREAKL 407
               :|.|:....:.|  |||.|               |.|.....|...|.:|.:..:.:...|.
Zfish   476 ---SPTPSSTDTVRS--DSPQR---------------GHSREPQDSEAQSHSNCNLPAHEHNRKN 520

  Fly   408 LQKQQQQQQQTYQQQQQRDSINNS-------YNRKDSLTNDTLLMCEELEPDEEGEYVLEEDNKQ 465
            .|...:...|.:|......:|.::       .||.|..::..:     .:|..:...::.:|: .
Zfish   521 FQTSVKTGYQFFQSTPLLSNIGSTSPAVPARLNRSDVKSSSPI-----RDPQIDRTQLVGKDS-P 579

  Fly   466 QRQRQQQQRYRQQQNQQRYEYYQNEDELEEQEEVEEEREEDQTHYDITNIETYQSGVGRGDDDDS 530
            ...|....:|.:..:...|                    :.|.|      :|.:   |..|..|.
Zfish   580 TLHRHLPTQYTRDNHTPTY--------------------DGQLH------DTLR---GHKDSPDI 615

  Fly   531 DRQCLVDDDDDDDAYDDEENDAGDEDYSTNSLGSGSAKQRLRALKQRTATRQQQRNRDAVDCAGR 595
            .|:.....:.|..|....:...|.|:..|            |..|.......|:||
Zfish   616 IRRSFTRPNTDTSATWTSQEKHGLEECFT------------RDKKSLMEVNNQKRN--------- 659

  Fly   596 SGSGSSSTTVKSEAGGLGLDETSFSVPTSPISLSTPLIDKETANSVPTS---------PEPSSLV 651
                                  |.:.|.||        |.....|||.|         .|.|...
Zfish   660 ----------------------SLNTPGSP--------DNHCGVSVPHSEIKGHNRAKKEWSGTA 694

  Fly   652 PESSSGAGAGAVVVRRH-NGHVVRKCDAAGFRTS-KSEDHLQQIQREGIAAVIPIDIDEDVNSSL 714
            .:||||.....|....| ..|:..:..:   ||| ||.|                        |.
Zfish   695 SQSSSGVKGSLVESTLHEKKHISSETSS---RTSQKSSD------------------------SG 732

  Fly   715 NTLLDTRQDSEDSQSMATVIVNNSSLA--------SNNNEGEQTDNRSSSSSSNSSDNNNCSSNT 771
            ||.:    .||::..:....:::..:|        .:::|.:||.:.|:.|||      .|||.:
Zfish   733 NTAI----QSENATCLQRPSLHSQKIARAKWEFLFGSHSEDQQTKDSSTPSSS------GCSSES 787

  Fly   772 GEP--------------------------ATSETATATATIIT-----ATSTRTMNCSSKLNY-- 803
            ..|                          :..:.......:|:     .||.:|......:.|
Zfish   788 PTPIPPLSTHLRPVTTHSRHYKSIGSSKSSCQDVQQVEVELISHHPTVGTSNKTGIIRRTVKYSE 852

  Fly   804 -------ILCKKASDRDRIVWTYNAPLQPHQLAALQRQQQQQEQQFQQQQQQLHQQ--------- 852
                   :.|.:.:|.|.::           ||    :|::.:..|...:..|...
Zfish   853 TDIDAVPLRCYRETDLDEVM-----------LA----EQEEVDSAFGSNRSVLGTSGTTSSSPLD 902

  Fly   853 -----HLQQQQQLQQQH-----QQQQQQQQQQQQQQLYGQQSHSNSHSSSISSSP-QHSAVGSPA 906
                 |...:::||.:.     ..:.|..:::|.....|.:..|......:...| .|:.:.||.
Zfish   903 GVLCPHTDGEEELQDEEVASWASVRMQGDKKRQNATPEGDEVFSRLLRGPLDYQPDSHTDLKSPI 967

  Fly   907 SPTS---VSS-----------SVMSSSGSKGA--LGLGS---SSNGPMAAVQQQQLREREQGGQV 952
            |.||   |||           |:|.|..:||.  ..|.|   :.:||............|...|:
Zfish   968 SVTSPCRVSSDCLDTFSRHFESIMESHRAKGTSYSSLDSEDITPSGPPIFTFDFPTLTPEIQSQI 1032

  Fly   953 AQPPSGIPGL----LSCPGGGCGNNGGGGGIGGGGNNDQSVSEAISNISSPD-YQDDDNLLSSRD 1012
            .:....|..|    |:||                  ...:||..|  ::|.| :::|.:.:...|
Zfish  1033 CESAKQITELNFASLTCP------------------EPPTVSHLI--VASQDLHREDRSSVCEED 1077

  Fly  1013 ILGGMVLS---------DPSDSDSTILVSDAAAHQRQQLKQQLRAQQQQQRERERDRDRDREQSE 1068
               |:..:         ..||||:|                          :|||. .|...:|:
Zfish  1078 ---GLFCTGSHSEQTHRPDSDSDAT--------------------------KRERP-SRPVSESD 1112

  Fly  1069 HKVVIQVRGLDSNSSGGNGTNGRSEEDVVTLTDEPLGTMTVGMRDASPPVSDDGSDVESLHSYHY 1133
            .:|..:: .|.|..:..||..
Zfish  1113 PEVAERL-ALGSTETLANGNK-------------------------------------------- 1132

  Fly  1134 SPKAVDMPSAIRLAKRLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTFEKKSLDQALREFL 1198
                .|:.:|.||||||::|||||||||:|||||||:||..||:|||.||.|....:|||||.||
Zfish  1133 ----ADLQAAKRLAKRLYTLDGFKKSDVARHLSKNNEFSHMVAEEYLSHFNFSGMMVDQALRVFL 1193

  Fly  1199 QQFSLSGETQERERVLVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRKMSCAEF 1263
            ::|:|.||||||||||.|||||:|.|||.|...:|:|||||||:|||||||||.|:.::|||.:|
Zfish  1194 KEFALMGETQERERVLSHFSKRYLQCNPKTIPYEDSVHTLTCALMLLNTDLHGHNVGKRMSCMQF 1258

  Fly  1264 VDNLADLNDGENFPKDVLKSLYQAIKTKPLEWALDEEAGDLQQQRA-----NNSALGNV-----G 1318
            :.||..||||::||||:||:||.:||.:.|:|.:|||  :|::..:     .:||...:     |
Zfish  1259 IGNLQGLNDGQDFPKDLLKALYNSIKNEKLQWTIDEE--ELRKSFSEMDGRKDSASHTMKRISSG 1321

  Fly  1319 LNPFLDPPELATAVEYKKGYVMRKCCYDSSFKKTPFGKRSWKMFYCTLRDLVLYLHKDEHGFRKS 1383
            .|..:...:.::|..||.|:::||...|...||||.|||.||.||..|:.|:|||.|||:...|.
Zfish  1322 GNSLISVAQQSSAQVYKNGFLVRKVHADPDGKKTPRGKRGWKTFYAILKGLILYLQKDEYRPDKQ 1386

  Fly  1384 QMSDNLHNAIRIHHALATKANDYTKKQHVFRLQTADQAEYLFQTSDSKELQSWVETINYVCAAIS 1448
            ...::|.||:.|||:||.:|.||:|:.:||.|:|||...:|||..:::::|||:..||.|.|..|
Zfish  1387 LSDEDLKNAVSIHHSLAMRAADYSKRPNVFYLRTADWRVFLFQAPNAEQMQSWITRINTVAAMFS 1451

  Fly  1449 APPLEGGVGSQKRFQRPLLPSKQSKLMLKEQLDSHEVQLAQLDQELNEHKKGP--IPSKGLALQN 1511
            |||....:||||:|.|||||...:||..:|||.|||.:...:..||.|.:..|  ..:|....:.
Zfish  1452 APPFPAAIGSQKKFSRPLLPGSNTKLSQEEQLKSHETRFRTVSAELQELRSTPQDRKTKSRDQEE 1516

  Fly  1512 YKEKESYLQYELRRYRTYVSILSAKMLADQQQLELQAQQPSPASHE----EEADTFPVGTTACTP 1572
            ||::|.||.:|..||.||..:|..|:...:..|         |:.|    |::.   :..|..:|
Zfish  1517 YKQREEYLDFEKTRYGTYTMLLRTKIRMGETDL---------AAFEGRLFEDSG---LQRTHSSP 1569

  Fly  1573 PTPQSINQKDQQKEQQQQQPTNRKEKKK 1600
            ..||.|:.....||..:....:.:..|:
Zfish  1570 TLPQDISHASSTKETSRSSSGSSRRTKR 1597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527	23/119 (19%)
		Sec7	1124..1293	CDD:238100	101/168 (60%)
		PH_EFA6	1330..1452	CDD:270107	58/121 (48%)
psda	XP_009305653.1	Sec7	1136..1288	CDD:238100	100/151 (66%)
		PH_EFA6	1332..1456	CDD:270107	59/123 (48%)