DRSC/TRiP Functional Genomics Resources

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Protein Alignment tHMG1 and HMGB2

DIOPT Version :10

Sequence 1:NP_651055.1 Gene:tHMG1 / 42650 FlyBaseID:FBgn0038978 Length:126 Species:Drosophila melanogaster
Sequence 2:NP_002120.1 Gene:HMGB2 / 3148 HGNCID:5000 Length:209 Species:Homo sapiens


Alignment Length:68 Identity:27/68 - (39%)
Similarity:41/68 - (60%) Gaps:5/68 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 PKKPMSAFMLWMNSTGRKHIKAEHPDFSVQEVSVKGGEMWRAMADEDKIVWQESATTAMAEYKEK 72
            ||:|.|||.|:. |..|..||:|||..|:.:.:.|.||||...:.:||..:::.|    |:.|||
Human    95 PKRPPSAFFLFC-SEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKA----AKLKEK 154

  Fly    73 LKQ 75
            .::
Human   155 YEK 157

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tHMG1NP_651055.1 HMG_box 8..76 CDD:459837 27/68 (40%)
HMGB2NP_002120.1 HMG-box_HMGB_rpt1 8..76 CDD:438794
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..150 23/59 (39%)
HMG-box_HMGB_rpt2 93..163 CDD:438795 27/68 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 162..209
Required for chemotactic activity. /evidence=ECO:0000269|PubMed:19811285 165..180
Blue background indicates that the domain is not in the aligned region.

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