DRSC/TRiP Functional Genomics Resources

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Protein Alignment tHMG1 and sox18

DIOPT Version :10

Sequence 1:NP_651055.1 Gene:tHMG1 / 42650 FlyBaseID:FBgn0038978 Length:126 Species:Drosophila melanogaster
Sequence 2:NP_001123409.1 Gene:sox18 / 100170185 XenbaseID:XB-GENE-483233 Length:362 Species:Xenopus tropicalis


Alignment Length:66 Identity:16/66 - (24%)
Similarity:24/66 - (36%) Gaps:19/66 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 YRCP--ANQMFVEGQCVQRDWSNMPPGTIVPYECVRPGLFADP--AHCRYYYSCNAELVATHLQC 90
            ||.|  ..::.:.||.|:..:            |....:|..|  :||....:| .|....|  |
 Frog   146 YRPPPRTKEVIINGQTVKLKY------------CFTCKIFRPPRASHCSLCDNC-VERFDHH--C 195

  Fly    91 P 91
            |
 Frog   196 P 196

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tHMG1NP_651055.1 HMG_box 8..76 CDD:459837 11/49 (22%)
sox18NP_001123409.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
HMG-box_SoxF_SOX18 65..144 CDD:438851
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:P43680 70..83
Interaction with DNA. /evidence=ECO:0000250|UniProtKB:P43680 94..106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 129..159 3/12 (25%)
Important for transcriptional activation. /evidence=ECO:0000250|UniProtKB:P43680 149..209 14/63 (22%)
Sox17_18_mid 173..222 CDD:463454 9/27 (33%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:P35713 307..315
Blue background indicates that the domain is not in the aligned region.

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