Protein Alignment CCT1 and Mkks

DIOPT Version :10

• Sequence 1: NP_524450.2
• Gene: CCT1 / 42649
• FlyBaseID: FBgn0003676
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: NP_067502.2
• Gene: Mkks / 59030
• MGIID: 1891836
• Length: 570
• Species: Mus musculus
• Alignment Length: 588
• Identity: 118/588 - (20%)
• Similarity: 225/588 - (38%)
• Gaps: 103/588 - (17%)

  Fly    22 TQNVMAALSI-SNIVKSSLGPVGLDKMLVDDIGD-VTVTNDGATILRLLEVEHPAAKVLVELAQL 84
            ::.|.:.||: ..::.|..||.|..|.|.:.:|. |..|:..:.:||.|.|.||..|:|....|.
Mouse    19 SEKVRSTLSVLKGVIASCYGPSGRLKQLHNGLGGCVYTTSQSSALLRNLSVTHPVLKILTSSVQN 83

  Fly    85 QDEEVGDGTTSVVILAAELLKNADEL-------VKQKIHPTSIISGYRIACKEACKYISEHLTAP 142
            ......|......||...|::|...|       :|...:..|:.:.|  ...|||.     ...|
Mouse    84 HVSCFSDCGLFTAILCCNLIENIQRLDLTPATAIKLNKYLLSLCTSY--LKSEACS-----CRIP 141

  Fly   143 VDELGRDSLINIAKTSMSSK----IIGADAEFFSAMVVDAAQSVKITDPRGQAAYSI--KAINVL 201
            ||.....:.:::..:.::||    :...:.:...|:::.|   ..:|.|.......:  |:| ::
Mouse   142 VDFRSTHTFLSLVHSILTSKPACMLTRKETDHIGALILKA---FLLTIPESTEERMVLGKSI-IV 202

  Fly   202 KAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIA--------CLDFSLQKTKMKMGVQVLIN 258
            ...|:...:|.::||..:.   ||:...::::..:.|        |...|...:....||.|...
Mouse   203 PLKGQRVTDSTVLPGLLIE---ASEVQLRRLLPTQKASGLRVALFCTSLSGDFSNAGEGVVVAHY 264

  Fly   259 DPDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKIIA 323
            ......|:..:.|::.:.    ::...|::||....:.....::|.|...||:.||..:.::.::
Mouse   265 QVSLENAVLEQLLNLGRR----LVTDHVDLVLCQKVIHPSLKQFFSERHVMAIDRVGVTLMESLS 325

  Fly   324 KATGAAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFYC 388
            |.|||..|.||      ....::..|...:|...|........:...:| ...:::|...||...
Mouse   326 KVTGATPIGSL------NPIVSTTYGSVKDVCSARFGSKHFFHLLPNEA-TVCTLLLCSRNDTAW 383

  Fly   389 DEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYLENFATSLA-----------SREQLAIA 442
            :|::.:...|:.|::..::...|:.||||.|..|:.|:.:.....|           ::..:|..
Mouse   384 EELKLTCQTAMHVLQLTIKEPWVLLGGGCTETHLAAYVRHKVHHEAEAIVRDDGCTQAKLHVAAE 448

  Fly   443 EFAKSLLVIPKTLSVNAAKDATD--------LVAKLRSYHNSSQTKP--------ERSDLKWTGL 491
            .|..:|..:..:|..:..:...|        ..|...|..|.|.|..        .:.:|.|:
Mouse   449 AFCSALESVAGSLEHDGGEILIDTKYGHLWSCQADSASVGNWSDTLSRCGCGLYNSQEELSWS-- 511

  Fly   492 DLIEGVVRDNKKAGVLEPAM-----------------SKIKSLKFATEAAITILRIDDMIKLNPE 539
                 |:|........:..:                 :|:..|:.|.|.|..||.:..:|    |
Mouse   512 -----VLRSTYHPFAPQTCLPQAALGSASNLTVDCFTAKLSGLQVAVETANLILDLSYVI----E 567

  Fly   540 DKS 542
            ||:
Mouse   568 DKN 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	115/582 (20%)
Mkks	NP_067502.2	Cpn60_TCP1	29..569	CDD:395068	113/575 (20%)
		Substrate-binding apical domain. /evidence=ECO:0000250|UniProtKB:Q9NPJ1	198..370		36/186 (19%)