DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCT1 and Mkks

DIOPT Version :9

Sequence 1:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001008354.1	Gene:	Mkks / 311456	RGDID:	1308814	Length:	570	Species:	Rattus norvegicus

Alignment Length:	586	Identity:	125/586 - (21%)
Similarity:	235/586 - (40%)	Gaps:	99/586 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TQNVMAALSI-SNIVKSSLGPVGLDKMLVDDIGD-VTVTNDGATILRLLEVEHPAAKVLVELAQL 84
            ::.|.:.||: ..|:.|..||.|..|.|.:.:|. |..|:..:.:||.|.|.||..|||....|.
  Rat    19 SERVRSTLSVLKGIIASCYGPSGRLKQLHNGLGGCVCTTSQSSALLRNLSVTHPILKVLTSSVQN 83

  Fly    85 QDEEVGDGTTSVVILAAELLKNADELVKQKIHPTSIIS------GYRIAC--KEACKYISEHLTA 141
            ......|......||...|::|...:   .:.||:.|.      |..|:.  .|||.     ...
  Rat    84 HVCCFSDCGLFTAILCCNLIENIQRI---GLTPTTAIKLNKYLLGLSISYLKSEACS-----CRI 140

  Fly   142 PVDELGRDSLINIAKTSMSSK----IIGADAEFFSAMVVDAAQSVKITDPRGQAAYSI--KAINV 200
            |||.....:.:|:..:.::||    :...:.:...|:::.|   ..:|.|.......:  |:| :
  Rat   141 PVDFRSTHTFLNLVHSILTSKPACMLTRKEIDHIGALILKA---FLLTIPESAEERMVLGKSI-I 201

  Fly   201 LKAHGKSARESVLIPGYALNCTIASQQMPKKI--------VNAKIACLDFSLQKTKMKMGVQVLI 257
            :...|:...:|.::||..:.   ||:...:::        :...:.|...|...:....|..|:.
  Rat   202 VPLKGQQVTDSTVLPGLLIE---ASEVQLRRLLPTQKSSTLRVALFCASLSGDFSNAGEGTLVVH 263

  Fly   258 NDPDKLEAIRARELDITKERINMILGTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKSDLKII 322
            .......|:..:.|::.::    ::...|::||....:.....::..|...:|:.||..:.::.:
  Rat   264 YQVSLENAVLEQLLNLGRQ----LVSDHVDLVLCQKVIHPSLKQFLSEHQIIAIDRVGVTLMEPL 324

  Fly   323 AKATGAAFITSLTNMDGEESFDASMVGEAAEVAQERICDDELILIKGTKARAAASIILRGPNDFY 387
            :|.|||..|.||      ....::..|...:|...|........:...:| ...|::|...||..
  Rat   325 SKVTGATPIGSL------YPIVSTTYGSVKDVRSARFGSKYFFHLLPNEA-TICSLLLCSRNDTA 382

  Fly   388 CDEMERSVHDALCVVKRVLESKKVVAGGGCVEAALSIYL----ENFATSL-----ASREQLAIA- 442
            .:|::.:...|:.|::..::...|:.||||||..|:.|:    .|.|.::     .|:.:|.||
  Rat   383 WEELKLTCQTAMHVLQLTIKEPWVLLGGGCVETHLAAYIRHKVHNEAEAIVRDDGCSQAELHIAT 447

  Fly   443 -EFAKSLLVIPKTLSVNAAKDATDLVAKLRSYHNSSQTKPERSDLKW--------TGL-----DL 493
             .|..:|    ::.:|:...|..:::..::..|..|......|...|        .||     :|
  Rat   448 EAFCSAL----ESAAVSLEHDGGEILIDMKYGHFWSCPADSASVGNWPDTLSRCGCGLYNSQEEL 508

  Fly   494 IEGVVRD------------NKKAG-----VLEPAMSKIKSLKFATEAAITILRIDDMIKLNPEDK 541
            ...|:|.            ...:|     .::...:|:..|:.|.|.|..||.:..:|    |||
  Rat   509 SWSVLRSTYHPFAPQTCLPQAASGSVSNLTVDSFTAKLSGLQVAVETANLILDLSYVI----EDK 569

  Fly   542 S 542
            :
  Rat   570 N 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	122/580 (21%)
Mkks	NP_001008354.1	Cpn60_TCP1	29..569	CDD:278544	120/573 (21%)
Mkks	NP_001008354.1	chaperonin_like	32..456	CDD:295468	99/453 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810