Protein Alignment CG12499 and Urb1

DIOPT Version :10

• Sequence 1: NP_651044.1
• Gene: CG12499 / 42637
• FlyBaseID: FBgn0038968
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: NP_083773.1
• Gene: Urb1 / 207932
• MGIID: 2146468
• Length: 2277
• Species: Mus musculus
• Alignment Length: 2260
• Identity: 479/2260 - (21%)
• Similarity: 815/2260 - (36%)
• Gaps: 692/2260 - (30%)

  Fly   159 LELAEAFERI--DKTNLFHVDYLTEALHRVLMEILTNQKSHMESAVHGCRYFLKVHGGVLENQMK 221
            :|.||.|:.:  :|.....:..:.:|...:|:. ..:..:|..  |.|.....|    :|.|.||
Mouse    76 MECAEIFQLLSGEKRPESEMLLIFQAFEAILLR-TASDLTHFH--VVGANIVKK----LLYNHMK 133

  Fly   222 SM-----QLGHR--RNALKLLTAIVCVEPQLARQVLNSYDVLSNVTVTQKLLSHEKSEYQCEDTV 279
            .:     ..|:|  |..|.|:||:|...|:.||.|.:|.|:  |......|::  |.:.:....|
Mouse   134 LLCESLYASGYRMARACLDLMTAMVTQGPEAARDVCSSLDL--NKKALFALVT--KRDSKGVHDV 194

  Fly   280 RKAFILFILAFLVEGNTLLIRNILDRGQLIG-VLAKGLVYDDHVTVCVVLNALRQYVLENPEIQK 343
            |.|:|.|.|:||:.|:...|..:|:..:.|. :.:.|:..|...|:.::|:.|:..|:.|..|.|
Mouse   195 RLAYIQFALSFLIAGDDNTIGQVLEIKEFIPCIFSSGIKEDKISTINILLSTLKTKVIHNKNITK 259

  Fly   344 TKKVLVFDLECCKNLRRLYDWEGPMGLKVMFAKSKHVSKIPPNPQEAEAVSA----------AVH 398
            |:||..|..:...::..||:|.|             ::.:.|...|:.|:||          .||
Mouse   260 TQKVRFFTGQFLNHIAALYNWNG-------------ITDVTPEKPESAAISAEEAGKAMVRDLVH 311

  Fly   399 ELLLVLLTSRKHGICF-DA------------MTHYRQKQNKLQGRLLGSLFKPYDNPRKVDLVIQ 450
            ..|:.|..||||||.| ||            :.|:           |.||.....:.....||:.
Mouse   312 NFLMDLCCSRKHGISFYDASLGTSGRGGNLTLLHF-----------LLSLKTAAGDDLVASLVVS 365

  Fly   451 TLTACPDLGRNTVRNCS-SLLSPVKTKPKDLPIAVAFLAQIINAVPPSALSAAFDKMTLTDFSFW 514
            .|..||||.....:..: |.|..||:...:   .|..|.:|..|.|  .:|.|          ||
Mouse   366 ILKVCPDLLTKYFKEVTFSFLPRVKSTWLN---NVKLLNKIYEAQP--EISPA----------FW 415

  Fly   515 IKELCLPIEALL--------HITGKKYLSDPDFNL-----RLAVLRLLLSMMK------------ 554
            .:|. :|:..||        .:...|.:.....||     :.:.|.|:..::|
Mouse   416 TREF-IPLPRLLAMVMVTTVPLVCNKIMFTQALNLDSIPVKHSALSLISDILKRALKTVDHCLDK 479

  Fly   555 ---QYSNYMNAIAVREQSKKAGNSLRKFKFDLLNHLLVHFPTIESILYSLYMF----IKQKNVEG 612
               |.|:...|..:.|..:....:|.|.           .|.:.::::....|    ||:.:.:|
Mouse   480 ETWQDSDVYTAEMMEEFVQLFREALGKI-----------LPDLNTVIWVWQSFKKQEIKEDHEKG 533

  Fly   613 V---------------NVLESLSITLDLVMLLCKENRAFVNKTSQILDYLDVLRPLYETDFDKL- 661
            .               :|.|::.:...|:.::|...:...:...|           |..||.||
Mouse   534 KKSSSKTPAVSKAAQHDVAETILLKSVLLQVICLYQQVVPHVIMQ-----------YNFDFSKLL 587

  Fly   662 ------NQPEE---------LLKIQLELKSIKTILLLFPHSLNPTQPLFG---NVF----KSFIK 704
                  ..|.:         :||:.|||.:.|.:.|....  .|...:.|   :||    |.|:.
Mouse   588 KGIISEQGPSQEVPPILQHHMLKVALELPANKFLWLKAQE--GPEAEIIGGERSVFYLLMKMFVN 650

  Fly   705 AYMLEEKSIKSESGNILSRLFQNTGMFDSCRHEINIWIEALIGFG----PATVTNVVEILLTILC 765
            :..|:   :||.:..::.::.::||:|:....|:.:|:|.|....    .|.:..:..||||::.
Mouse   651 SNHLQ---LKSSTKLLIMKILRDTGVFEHTWRELELWLEHLDSTAEERKEAVIQFLERILLTLVM 712

  Fly   766 LDWR---------------QIELPEQSVTDTAIITKNLSKLFAQIE---QGQ-----------TV 801
            ..:.               |..:.:|...|.:|...::..:...::   :|.           ..
Mouse   713 NPYSYTDKASEFVQEASTLQASMGKQDADDVSIPISHIDDVLDMVDVLVEGSEGLDEDIGFLLNE 777

  Fly   802 QAYVETLTLSKMMPL-------LLKGVELE--EPYDEYVELVFVLLFHYHSKPE---IVLQMYE- 853
            ...:.|...|.::|.       ||.|.:.|  |....|:..|...|.|....|.   ::||.|:
Mouse   778 DMILLTFPFSALVPAALEARNKLLLGTDCEAGESIMAYMTAVLTDLLHTQRDPLALCLLLQSYDK 842

  Fly   854 ---------DNLSKHTNYMKSWLPGE----------GNGKPKKLP---------------HLIFD 884
                     ..|::...|...|:|.:          .:..|..||               ..:.|
Mouse   843 FEPVSLLCGQQLAQFHRYYSLWIPAQAQEALPLQVSSSSGPCTLPPSSCFSTLLQTAYESQTLGD 907

  Fly   885 K---WPLLKQMRKVSTESENMSFEQV-FKMDDTENNFELQLEEGQTM---LLHSSLGNPRRNMIY 942
            |   ..||..:..::.:....|.:|| ..:..|..||. ||  |:::   ||.|.||..::.:|:
Mouse   908 KSVQAQLLAAVPSLALQHMLRSAKQVLLYLKSTVENFS-QL--GRSVGPALLQSLLGLLKQLVIH 969

  Fly   943 VQDLLFVFSHFFTSQKLSKPQAELTADFLIKFLQIASQVDGPEEVQESDDEQQDE---------- 997
            .:.|     .....|||...:||  :|..:....:||       ::.:.|:..:|
Mouse   970 AERL-----DAQNQQKLEAARAE--SDLFLDMESVAS-------LELATDKTIEELLLAILKHPT 1020

  Fly   998 ----------------------------NFTQSMLHYI-----FNHRLWQLHPTELLSETSESRL 1029
                                        :|:..:|..:     ..|:|.||   .||::.||:..
Mouse  1021 LETWFLALEQKALPPHTLSPILVKLLAAHFSAGVLQLLVASSPILHKLGQL---GLLAKYSEAIT 1082

  Fly  1030 NYVIF-LR-RLMEHC---RSLPRFETYTANYRLH------LIKTLDIAL----------DTPVDQ 1073
            ..|:. || |.:...   ::||:.|   |...||      .|:.:.:||          ......
Mouse  1083 QSVLIELRTRTLNSTSTPKTLPQLE---ALRELHPYMEGVQIREVTLALLALPEAHLLTQQGTQS 1144

  Fly  1074 LGNQQQLDE----CVKLVDSFEFNSDQCSQML----------DLLTTKVQAKDCIPNGKPNHYFD 1124
            ||.::.|..    .|:|:.|...:..|.|::|          .||.|..:           |..|
Mouse  1145 LGKERHLSSLGKTLVQLLASSHQDQLQSSELLWCAEYVRGLGALLPTLAE-----------HELD 1198

  Fly  1125 LLLRLLGRLNTL-KEPIDCGKSFKLILTFYKDFGELNEQQLEPFELAVLEFLLNYHHHMDECDSE 1188
            .:.     |.|| |:|:                       |.|   .|.|.:|.|
Mouse  1199 TVF-----LQTLQKDPV-----------------------LAP---VVPEGVLEY---------- 1222

  Fly  1189 FFACFFTSSRKLSKSAIRLACLLLE-------------RQPRLAETFAELLPSNLEQKDLVYPLL 1240
               |.    .:.:::|:.:|.|||:             .||.:..|..|.|       |..:||:
Mouse  1223 ---CL----ARRTQTALGIASLLLQYSGTHLVKFELWCGQPGVGPTLQEHL-------DDFFPLI 1273

  Fly  1241 DIALTKNYQ-----------IPLPVLQRCYQTYKNGFMKSIEKPQKAALIYREHSEASALLIALC 1294
            .:.|....|           ...|||:..::..::.|. .|..|.|.||    |.||.|.||.
Mouse  1274 HVYLQHRAQGSFMRPTGVSSAVTPVLKALWRQVRDRFF-HITGPSKDAL----HLEALAQLIP-- 1331

  Fly  1295 MPKSECFDYCQKQLKLDSVELFQVRVLREIYWQGFAAAKDEKQKATVFVNYINLNVQLLA----- 1354
                                              ||..||    ..|.::::...::.|:
Mouse  1332 ----------------------------------FARTKD----LHVLMDHLPNTLRTLSNHKSW 1358

  Fly  1355 --LDLKKQALDLPKLEQISW------NCYEWWKTNRTDDLPLDWS----------RLQK------ 1395
              .|....||.....|..||      :|.:|...:.:...|.|.:          ||.:
Mouse  1359 TLADSVSAALAESAEELGSWRKTLLRSCIQWLAVSFSGREPEDENTQEHEKAMLVRLSELLHAVK 1423

  Fly  1396 --NP-QWLNFCKSSLKLALH--------LGEERLPLQDETNGLVLKLMAFLCDGMYDEYKEDAQQ 1449
              :| .|..|.|:.||...|        |...:|....|::|.. ||:..
Mouse  1424 EVDPGDWQQFVKTGLKFRYHDLTFLKTLLSATKLLYGPESSGRT-KLVQL--------------- 1472

  Fly  1450 EEDATPTLLYEMICTHSCCFDHLLGKPSE------TKTHILHLMEVLARKAPSALQSDHIPVILG 1508
                  ::::.|:..||.....:|....|      .|..:|.||..:.|..||..||.|..|:||
Mouse  1473 ------SVVHMMLTQHSLFLPTMLSSEEEETPDSGVKETLLDLMSTVVRLCPSVCQSSHFAVLLG 1531

  Fly  1509 SYHAKLSPADRYGLALLEHYERFDVGLDKFRPFIWGESAVAHY-ALRAADEDVRTRLQQQETNVA 1572
            :|.|.||..|:..|.||..||:.::.|..||..:||.:||.|: ..|:..:.:     .|:.:|.
Mouse  1532 TYSATLSVLDQKILLLLRAYEQNNLSLISFRVLLWGPAAVEHHKTCRSLGKSL-----WQQPSVG 1591

  Fly  1573 QVLALIVRETSEYTIENFPIWRSLHASQQLPSTEFQNPAKKSMSFGDNQLEQMVEQGQLDFPQDL 1637
            .:|.|:..:....||.:||.:|.|     ||:.:...|    :.|.|       :..::|.
Mouse  1592 DILRLLDPDRMMQTILHFPQYRKL-----LPTEDTGEP----LVFKD-------KTARVDL---- 1636

  Fly  1638 RRICPKRETIYETCYDPAFLLPLMMHCFAPESVVWARWPVQNGLLAITFCGLSSLDKDMRLAAAS 1702
                       ::.|||.|||.|......||.||..|..:.:..|.:|...|||.|..||.||..
Mouse  1637 -----------DSLYDPCFLLHLFGELTRPEFVVDCRKFLDSNALGLTVAALSSYDPQMRAAAYY 1690

  Fly  1703 CQQRYRAHFELSNFYERPLWTQAYENIQAGLADLRNSWLAQRRTHGGTP--RVPLIPGLFIAHSF 1765
            ....|.:|.|.:.|.|:.......:.::.|:.               ||  |:|....||||.:.
Mouse  1691 VLAAYYSHLEGARFREQSQVLYLLDVVRNGIR---------------TPNLRLPFTVALFIAKAA 1740

  Fly  1766 NLSTEPTHLLYKRLMMYLRLKQSFNFQTIPDFNVFFYSQEPEHQQYREFIVELLRCGIKCSADLF 1830
            ....:|...:|.::..:|...::.|...:|.|..||||.:.:.:..:|:::|:||.||:......
Mouse  1741 VQILKPEEHMYWKISKFLLSHENLNMDKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCYE 1805

  Fly  1831 LLVSTNTFKVLLGFYGSSLASLETNLLLLSVLSTCVKIPGAVKIMLEHVGILSWLVGVIRDTEFH 1895
            |......|.::|.|:.|.|........:|.:|.....|..:...::....:|:|::.:: ::.|.
Mouse  1806 LCSRRGVFHIILSFFNSPLCDEVAQNWILEILQNVAHITRSAYEVIRDYSLLTWVLHIL-ESRFV 1869

  Fly  1896 QFDIIEGVISILNNLWYA----------------LAASRSELTDYDHIQLRVYRLVLQLLPLLSP 1944
            :..::..|||:|:.||..                :.:..||.....|:......:::.|...|.|
Mouse  1870 ETQLLSNVISLLHTLWVTNLGNKAPEERSQPPGQVGSQESEKMLALHMVSEFLYVLIALTKHLRP 1934

  Fly  1945 RISVPGLGRLFNVLWKTGSACGQHRAVSATQMDTLLECVSRQWPDQLASVRYVRSFGSAGACSRS 2009
            .::   ..:|.|..|...|.. .:||       |:::
Mouse  1935 TLA---SAQLMNFFWTLESVL-SYRA-------TIIK---------------------------- 1960

  Fly  2010 EYCDWLAKDQKLETPAVLALSSLREYVI--DWAQAHK-SESDGETKLLVE 2056
                 |.||....|...:|||:....::  .|:...: ::..||.|.::|
Mouse  1961 -----LFKDMGRFTVNKVALSTKDVLILLHKWSLIERDTKLQGELKAVIE 2005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12499	NP_651044.1	Npa1	160..472	CDD:463325	92/345 (27%)
		NopRA1	1682..1884	CDD:465063	50/203 (25%)
Urb1	NP_083773.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		Npa1	78..396	CDD:463325	93/355 (26%)
		NopRA1	1670..1859	CDD:465063	50/203 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2023..2045