Protein Alignment CAH8 and CA9

DIOPT Version :10

• Sequence 1: NP_651033.2
• Gene: CAH8 / 42625
• FlyBaseID: FBgn0038956
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: NP_001207.2
• Gene: CA9 / 768
• HGNCID: 1383
• Length: 459
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 88/269 - (32%)
• Similarity: 125/269 - (46%)
• Gaps: 40/269 - (14%)

  Fly    30 YKSPERWPEKYPNCGGSEQSPIAISRRKAI------PL-----NLPPLIFALYDEFFDELVTIRN 83
            |.....||...|.|.|..|||:.|..:.|.      ||     .||||         .|| .:||
Human   143 YGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPL---------PEL-RLRN 197

  Fly    84 SGHTVEFKVPTTIYGVKPYVTGGLLRDCYDAEAVHFHWGSPESKGSEHLLNGRRFDLEMHIVHRN 148
            :||:|:..:|.   |::..:..|  |: |.|..:|.|||:....||||.:.|.||..|:|:||.:
Human   198 NGHSVQLTLPP---GLEMALGPG--RE-YRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLS 256

  Fly   149 TKYLNLEEAVKYSDGVTVLAVLFKVVRSGPFFYQPGLSEIFSSLLHLGNFNASYTVQERLTLGSL 213
            |.:..::||:....|:.|||..   :..|| .......::.|.|..:.. ..|.|....|.:.:|
Human   257 TAFARVDEALGRPGGLAVLAAF---LEEGP-EENSAYEQLLSRLEEIAE-EGSETQVPGLDISAL 316

  Fly   214 LGSLDRGNFYTYKGSLTTPPCSPVVQWHVFGEVLPISHQDL----PKFWNLRDERGRPLLKNFRP 274
            |.| |...::.|:||||||||:..|.|.||.:.:.:|.:.|    ...|...|.|   |..|||.
Human   317 LPS-DFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSR---LQLNFRA 377

  Fly   275 LQSQENRLI 283
            .|....|:|
Human   378 TQPLNGRVI 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH8	NP_651033.2	Carb_anhydrase	33..286	CDD:459707	87/266 (33%)
CA9	NP_001207.2	Proteoglycan-like (PG)	38..112
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..154		3/10 (30%)
		PHA03169	<44..>148	CDD:223003	1/4 (25%)
		Catalytic. /evidence=ECO:0000269|PubMed:19805286	138..391		88/269 (33%)
		alpha_CA_IX	145..391	CDD:239403	87/267 (33%)