Protein Alignment CAH8 and CA3

DIOPT Version :10

• Sequence 1: NP_651033.2
• Gene: CAH8 / 42625
• FlyBaseID: FBgn0038956
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: NP_005172.1
• Gene: CA3 / 761
• HGNCID: 1374
• Length: 260
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 77/282 - (27%)
• Similarity: 122/282 - (43%)
• Gaps: 64/282 - (22%)

  Fly    30 YKSPERWPEKYPNCGGSEQSPIAISRR--KAIPLNLPPLIFALYDEFFDELVTIRNSGHTVEFKV 92
            :..|:.|.|.:||..|..|||:.:..:  :..| :|.|...: ||.  ....||.|:|.|.....
Human    10 HNGPDHWHELFPNAKGENQSPVELHTKDIRHDP-SLQPWSVS-YDG--GSAKTILNNGKTCRVVF 70

  Fly    93 PTTIYGVKPYVTGGLLRDCYDAEAVHFHWGSPESKGSEHLLNGRRFDLEMHIVHRNTKYLNLEEA 157
            ..| |. :..:.||.|...|.....|.||||.:..||||.::|.::..|:|:||.|.||...:||
Human    71 DDT-YD-RSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEA 133

  Fly   158 VKYSDGVTVLAVLFKVVRSGPFFYQPGLSEIFSSLLHLGNFNASYTVQERLTLGSLLGSLDR--- 219
            :|..||:.|:.:..|:                      |:.|..:.:        .|.:||:
Human   134 LKQRDGIAVIGIFLKI----------------------GHENGEFQI--------FLDALDKIKT 168

  Fly   220 -------------------GNFYTYKGSLTTPPCSPVVQWHVFGEVLPISHQDLPKFWNL----R 261
                               .:::||:||.|||||...:.|.:..|.:.:|...:.|..:|    .
Human   169 KGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAE 233

  Fly   262 DERGRPLLKNFRPLQSQENRLI 283
            :|...||:.|:||.|...||::
Human   234 NEPPVPLVSNWRPPQPINNRVV 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH8	NP_651033.2	Carb_anhydrase	33..286	CDD:459707	77/279 (28%)
CA3	NP_005172.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	77/282 (27%)
		Involved in proton transfer. /evidence=ECO:0000269|PubMed:17427958	64..67		1/2 (50%)