Protein Alignment CAH8 and CA1

DIOPT Version :10

• Sequence 1: NP_651033.2
• Gene: CAH8 / 42625
• FlyBaseID: FBgn0038956
• Length: 303
• Species: Drosophila melanogaster
• Sequence 2: NP_001729.1
• Gene: CA1 / 759
• HGNCID: 1368
• Length: 261
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 84/270 - (31%)
• Similarity: 129/270 - (47%)
• Gaps: 26/270 - (9%)

  Fly    25 STDFDY---KSPERWPEKYPNCGGSEQSPIAISRRKA-IPLNLPPLIFALYDEFFDELVTIRNSG 85
            |.|:.|   ..||:|.:.||...|:.|||:.|...:. ...:|.|:..:.......|::.:.:|.
Human     3 SPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSF 67

  Fly    86 HTVEFKVPTTIYGVKPYVTGGLLRDCYDAEAVHFHWGSPESKGSEHLLNGRRFDLEMHIVHRNT- 149
            | |.|:....    :..:.||...|.|.....||||||....||||.::|.::..|:|:.|.|:
Human    68 H-VNFEDNDN----RSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSA 127

  Fly   150 KYLNLEEAVKYSDGVTVLAVLFKVVRSGPFFYQPGLSEIFSSL--LHLGNFNASYTVQERLTLGS 212
            ||.:|.||...:||:.|:.||.||..:     .|.|.::..:|  :......|.:|..:..||
Human   128 KYSSLAEAASKADGLAVIGVLMKVGEA-----NPKLQKVLDALQAIKTKGKRAPFTNFDPSTL-- 185

  Fly   213 LLGSLDRGNFYTYKGSLTTPPCSPVVQWHVFGEVLPISHQDLPKF----WNLRDERGRPLLKNFR 273
            |..|||   |:||.||||.||....|.|.:..|.:.:|.:.|.:|    .|:..:...|:..|.|
Human   186 LPSSLD---FWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNR 247

  Fly   274 PLQSQENRLI 283
            |.|..:.|.:
Human   248 PTQPLKGRTV 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH8	NP_651033.2	Carb_anhydrase	33..286	CDD:459707	81/259 (31%)
CA1	NP_001729.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		10/27 (37%)
		alpha_CA	2..261	CDD:469577	84/270 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..261		6/17 (35%)